RADIOTHERAPY AND ANEMIA - THE CLINICAL-EXPERIENCE
RADIOTHERAPY AND ANEMIA - THE CLINICAL-EXPERIENCE
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DOI：
10.1016/0167-8140(91)90184-i
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发表时间：
1991-01-01
影响因子：
5.7
通讯作者：
DISCHE, S
中科院分区：
文献类型：
--
作者：
DISCHE, S
文献综述表明，与在多个部位接受肿瘤放射治疗的表面相似但非贫血的患者相比，贫血的前景受损。一些不利的关联可能是因为，与同一部位和相同临床分期的非贫血患者相比，贫血患者实际上可能患有更晚期的疾病。然而，有充分的证据表明，贫血患者的肿瘤对放射治疗的反应会受损，尤其是在宫颈癌中。如果放射治疗的目的是治愈，则在治疗开始前必须恢复血红蛋白水平。在过去的 60 年里，人们对贫血与放射治疗反应之间的关系非常感兴趣。在 25 个寻求贫血影响的系列案例中，有 23 个发现了不利影响。然而，对这些论文的检查揭示了一种复杂的模式，需要进行一些分析。贫血本身需要定义。如图 1 所示，男性和女性的正常范围不同，并且公认的正常范围也存在一些差异。血红蛋白水平通常以 g% 为单位，但也以 mmol/l 表示。还有一些报告提到了血细胞比容。第一次出现时的血红蛋白值可能会被记录，但在开始治疗时，图像可能会因为出血或输血而改变。在检查报告时，有时不容易知道哪个值与响应相关。（摘要截断为 250 字）
Review of the literature shows good evidence of an impaired outlook for anaemic compared with apparently similar, but non-anaemic patients, treated by radiotherapy for tumors at a number of sites. Some of the adverse associations, may be because anaemic patients, compared with the non-anaemic at the same site and with the same clinical stage, may have in actuality a more advanced disease. However, there is good evidence, especially in carcinoma of the cervix, that there occurs an impairment of the response of tumor to radiotherapy in anaemic patients. Where cure is the object of radiotherapy, restoration of the haemoglobin level is necessary before the course is begun. During the past 60 years there has been much interest in the relationship between anaemia and response to radiotherapy. In 25 series of cases where an effect of anaemia has been sought an adverse influence has been found in 23. An examination of these papers, however, reveals a complex pattern demanding some analysis. Anaemia itself requires definition. As can be seen in Fig. 1, there are different normal ranges for men and women and there is some variation in what is accepted as normal. Haemoglobin levels are commonly given in g%, but they are also expressed as mmol/l. There are also reports which refer to the haematocrit. The haemoglobin value at first presentation may be recorded, but the picture may change by the time treatment is instituted, either because of haemorrhage or because of blood transfusion. In examining reports it is sometimes not easy to know which value is related to response.(ABSTRACT TRUNCATED AT 250 WORDS)