Stimulus-specific adaptation in the inferior colliculus of the anesthetized rat.
Stimulus-specific adaptation in the inferior colliculus of the anesthetized rat.
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DOI：
10.1523/jneurosci.4153-08.2009
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发表时间：
2009-04-29
期刊：
影响因子：
--
通讯作者：
Covey E
中科院分区：
文献类型：
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作者：
Malmierca MS;Cristaudo S;Pérez-González D;Covey E
要识别新的声音，必须有一些常见声音的神经表征。刺激特异性适应（SSA）是一种对重复声音的神经反应减少。以前的研究使用一个古怪的刺激范式表明，SSA发生在皮层，但这项研究表明，下丘（IC）的神经元也显示出强烈的SSA使用这种范式。大多数（66%）IC神经元表现出一定程度的SSA。约18%的神经元表现出近乎完全的SSA。在整个IC中发现SSA神经元。IC神经元的反应主要是在反应的起始部分减少，并且对oddball刺激的反应潜伏期比对标准刺激的反应潜伏期短。具有接近完整SSA的神经元被广泛地调谐到频率，这表明高度的收敛。因此，一些可能构成新奇感检测和对常见声音的行为习惯化的机制已经在中脑得到了很好的发展。
To identify sounds as novel, there must be some neural representation of commonly occurring sounds. Stimulus-specific adaptation (SSA) is a reduction in neural response to a repeated sound. Previous studies using an oddball stimulus paradigm have shown that SSA occurs at the cortex, but this study demonstrates that neurons in the inferior colliculus (IC) also show strong SSA using this paradigm. The majority (66%) of IC neurons showed some degree of SSA. About 18% of neurons showed near-complete SSA. Neurons with SSA were found throughout the IC. Responses of IC neurons were reduced mainly during the onset component of the response, and latency was shorter in response to the oddball stimulus than to the standard. Neurons with near-complete SSA were broadly tuned to frequency, suggesting a high degree of convergence. Thus, some of the mechanisms that may underlie novelty detection and behavioral habituation to common sounds are already well-developed at the midbrain.