Detection of Candida auris Antifungal Drug Resistance Markers Directly from Clinical Skin Swabs
Detection of Candida auris Antifungal Drug Resistance Markers Directly from Clinical Skin Swabs
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DOI：
10.1128/aac.01754-19
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发表时间：
2019-12-01
影响因子：
4.9
通讯作者：
Perlin, David S.
中科院分区：
文献类型：
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作者：
Kordalewska, Milena;Lee, Annie;Perlin, David S.
准确和快速评估耳念珠菌抗真菌药物耐药性对于有效的感染预防和控制措施以及患者管理至关重要。在此，在一组临床皮肤拭子上评估了分子诊断平台的性能，该平台能够快速鉴定分别赋予棘白菌素和唑类耐药的FKS 1和ERG 11突变。基因测序和抗真菌药敏试验作为金标准。所有拭子均正确分类为携带野生型或突变型C。耳。
Accurate and rapid assessment of Candida auris antifungal drug resistance is crucial for effective infection prevention and control actions, as well as for patient management. Here, performance of a molecular diagnostic platform, enabling rapid identification of FKS1 and ERG11 mutations conferring echinocandin and azole resistance, respectively, was evaluated on a panel of clinical skin swabs. Gene sequencing and antifungal susceptibility testing were used as the gold standard. All swabs were correctly categorized as harboring wild-type or mutant C. auris.