Neural responses to affective speech, including motherese, map onto clinical and social eye tracking profiles in toddlers with ASD.
Neural responses to affective speech, including motherese, map onto clinical and social eye tracking profiles in toddlers with ASD.
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对情感言语（包括母亲语）的神经反应映射到患有自闭症谱系障碍（ASD）幼儿的临床和社交眼动追踪档案。
DOI：
10.1038/s41562-021-01237-y
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发表时间：
2022
影响因子：
29.9
通讯作者：
Courchesne,Eric
中科院分区：
文献类型：
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作者：
Xiao,Yaqiong;Wen,TeresaH;Kupis,Lauren;Eyler,LisaT;Goel,Disha;Vaux,Keith;Lombardo,MichaelV;Lewis,NathanE;Pierce,Karen;Courchesne,Eric
情绪化的语言，包括母亲的话，会吸引婴儿的注意力，并促进社交、语言和情感的发展。对情绪化语言的行为反应减少和照顾者与儿童的互动减少是婴儿自闭症的早期迹象。为了理解这一点，我们使用自然睡眠功能磁共振成像测量了轻度情感言语、中度情感言语和母亲语的神经反应，并使用眼睛跟踪技术测量了典型发育中的幼儿和自闭症儿童对母亲语的行为偏好。通过使用相似网络融合将不同的神经-临床数据结合在一起，我们发现了四个不同的幼儿群体。对情绪性言语的优势时间反应最弱、社交和语言能力非常差的自闭症群体降低了对母亲的行为偏好，而对情感言语的优势时间反应最强的典型发展群体则显示出相反的效果。我们的结论是，自闭症患者对母亲语言的行为偏好显著降低，这与通常对父母情感言语做出反应的颞叶皮质系统的发育受损有关。
Affective speech, including motherese, captures an infant’s attention and enhances social, language and emotional development. Decreased behavioural response to affective speech and reduced caregiver–child interactions are early signs of autism in infants. To understand this, we measured neural responses to mild affect speech, moderate affect speech and motherese using natural sleep functional magnetic resonance imaging and behavioural preference for motherese using eye tracking in typically developing toddlers and those with autism. By combining diverse neural–clinical data using similarity network fusion, we discovered four distinct clusters of toddlers. The autism cluster with the weakest superior temporal responses to affective speech and very poor social and language abilities had reduced behavioural preference for motherese, while the typically developing cluster with the strongest superior temporal response to affective speech showed the opposite effect. We conclude that significantly reduced behavioural preference for motherese in autism is related to impaired development of temporal cortical systems that normally respond to parental affective speech.