Iron deficiency in preschool children with autistic spectrum disorders
Iron deficiency in preschool children with autistic spectrum disorders
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DOI：
10.1016/j.rasd.2009.12.008
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发表时间：
2010-10-01
影响因子：
2.5
通讯作者：
Uslu, Runa
中科院分区：
文献类型：
--
作者：
Bilgic, Ayhan;Gurkan, Kagan;Uslu, Runa
铁缺乏对婴幼儿的心理和行为发育有不良影响。患有自闭症谱系障碍（ASD）的儿童有患ID的风险，这种情况可能会增加心理和行为问题的严重程度，其中一些问题本来就存在于这些儿童中。在本研究中，ID的频率和ID和自闭症症状，发展水平和行为问题的学龄前儿童参加ASD诊所（N = 31）之间的关联进行了评估。孤独症的严重程度、发展水平和行为问题与智力缺陷之间没有相关性。根据血清铁蛋白水平，在32.3%（N = 10）的儿童中检测到ID。在这项研究中，低血清铁蛋白对ASD的负面影响尚未得到证实。另一方面，与学龄前儿童的正常数据相比，ASD儿童样本中的ID率相当高。需要更大样本的进一步研究来阐明ID和ASD相关临床变量之间的关系。(C)2009爱思唯尔有限公司版权所有。
Iron deficiency (ID) cause negative outcomes on psychomotor and behavioral development of infants and young children. Children with autistic spectrum disorders (ASD) are under risk for ID and this condition may increase the severity of psychomotor and behavioral problems, some of which already inherently exist in these children. In the present study, the frequency of ID and the association between ID and autistic symptoms, developmental level, and behavioral problems in preschool children attending a clinic for ASD (N = 31) were evaluated. No association was observed between ID and the severity of autistic symptoms, developmental level and behavioral problems. ID was detected in 32.3% (N = 10) of the children based on serum ferritin level. In this study, the negative impact of low serum ferritin in ASD has not been confirmed. On the other hand, the rate of ID was considerably high in this sample of children with ASD compared to normative data of preschool children. Further studies with larger samples are needed to clarify the relationship between ID and clinical variables associated with ASD. (C) 2009 Elsevier Ltd. All rights reserved.