Heterochromatin: A meiotic matchmaker?
Heterochromatin: A meiotic matchmaker?
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DOI：
10.1016/s0962-8924(97)01034-9
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发表时间：
1997-05-01
影响因子：
19
通讯作者：
Gasser, SM
中科院分区：
文献类型：
--
作者：
Renauld, H;Gasser, SM
在减数分裂期间，染色体配对对于遗传物质的成功分配及其传递到发育中的配子中至关重要。减数分裂配对的经典观点包括同源物之间的重组作为配对机制的一个组成部分。但是，在没有重组发生的情况下，染色体伴侣如何找到彼此？他们如何配对，然后适当地隔离？最近，分子遗传学和荧光原位杂交的结合似乎已经提供了一个答案，这些问题的异染色质在染色体配对中发挥着至关重要的作用。
During meiosis, the pairing of chromosomes is crucial for a successful partitioning of the genetic material and its transmission into the developing gamete. The classical view of meiotic pairing involves recombination between homologues as art integral part of the pairing mechanism. But, in cases where no recombination occurs, how do chromosome partners find one another? And how do they pair up and then segregate appropriately? Recently, a combination of molecular genetics and fluorescence in situ hybridization appears to have provided an answer to these questions by demonstrating a crucial role for heterochromatin in chromosome pairing.