Natural RNA interference directs a heritable response to the environment.
Natural RNA interference directs a heritable response to the environment.
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DOI：
10.1038/srep07387
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发表时间：
2014-12-09
影响因子：
4.6
通讯作者：
Hunter CP
中科院分区：
文献类型：
--
作者：
Schott D;Yanai I;Hunter CP
RNA干扰可以诱导可遗传的基因沉默，但类似的机制是否在对野生环境中发生的线索的反应中发挥普遍作用仍有待探索。我们表明，短暂的，温和的热应激线虫线虫的信使RNA水平的变化，持续超过一代的结果。受影响的转录物富含皮尔纳途径下游的生殖系siRNA靶向的基因，并且生殖系RNAi缺陷的蠕虫对于这些遗传效应是有缺陷的。我们的研究结果表明，一个特定的siRNA途径传递信息的世代之间的可变环境条件。
RNA interference can induce heritable gene silencing, but it remains unexplored whether similar mechanisms play a general role in responses to cues that occur in the wild. We show that transient, mild heat stress in the nematode Caenorhabditis elegans results in changes in messenger RNA levels that last for more than one generation. The affected transcripts are enriched for genes targeted by germline siRNAs downstream of the piRNA pathway, and worms defective for germline RNAi are defective for these heritable effects. Our results demonstrate that a specific siRNA pathway transmits information about variable environmental conditions between generations.