BMPR2 and HIF1-α overexpression in resected osteosarcoma correlates with distant metastasis and patient survival
BMPR2 and HIF1-α overexpression in resected osteosarcoma correlates with distant metastasis and patient survival
复制标题
切除骨肉瘤中 BMPR2 和 HIF1-α 过度表达与远处转移和患者生存相关
DOI：
10.21147/j.issn.1000-9604.2017.05.09
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发表时间：
2017-10-01
影响因子：
5.1
通讯作者：
Guo, Wei
中科院分区：
文献类型：
--
作者：
Wang, Shidong;Ren, Tingting;Guo, Wei
目的：骨形态发生蛋白受体2 （BMPR2）和缺氧诱导因子1- α (hif1 - α)在几种类型的肿瘤中存在异常表达。然而，它们在骨肉瘤中的表达及其相关作用在很大程度上是未知的。方法：采用免疫化学方法分析103例骨肉瘤标本中BMPR2和hif1 - α的表达水平，探讨BMPR2和hif1 - α在骨肉瘤中的临床意义。同时，我们对骨肉瘤患者的转移行为和总生存率（OS）进行了随访。结果：103例组织中，bmpr2阳性表达61例，hif1 - α阳性表达57例。骨肉瘤标本中BMPR2与hif1 - α表达显著相关（P=0.035）。计算受试者工作特征（ROC）曲线，探讨两种标志物对肿瘤转移的预测价值。通过单因素和多因素分析，发现BMPR2和hif1 - α表达以及较高的肿瘤分级是骨肉瘤患者发生骨肉瘤的重要危险因素。Kaplan-Meier生存分析显示，与BMPR2阴性或hif1 - α阴性染色的患者相比，BMPR2和hif1 - α阳性表达的患者的OS更差。结论：BMPR2和hif1 - α表达与骨肉瘤患者的转移行为高度相关，可作为骨肉瘤患者转移和OS的预测指标。
Objective: Bone morphogenetic protein receptor 2 (BMPR2) and hypoxia-inducible factor 1-alpha (HIF1-alpha) existed abnormal expression in several types of cancer. However, their expressions and related roles in osteosarcoma are largely unknown.Methods: To investigate the clinical significance of BMPR2 and HIF1-alpha in osteosarcoma, we analyzed their expression levels in 103 osteosarcoma specimens by immunochemistry. Meanwhile, we conducted a follow-up to examine the metastatic behavior and overall survival (OS) of osteosarcoma patients.Results: Among 103 tissues, 61 cases had BMPR2-positive expression and 57 cases had HIF1-alpha positive expression. A significant correlation was noticed between BMPR2 and HIF1-alpha expression in osteosarcoma specimens (P=0.035). Receiver-operating characteristic (ROC) curves were calculated to investigate the predictive value of the two markers in tumor metastasis. By means of univariate and multivariate analysis, BMPR2 and HIF1-alpha expression, as well as higher tumor grade, were identified as significant risk factors for OS in patients with osteosarcoma. Kaplan-Meier survival analysis revealed that the patients with BMPR2 and HIF1-alpha positive expression had worse OS compared with patients with BMPR2-negative or HIF1-alpha-negative staining.Conclusions: It can be concluded that BMPR2 and HIF1-alpha expression is highly correlated with metastatic behavior in patients with osteosarcoma and can serve as predictive markers for metastasis and OS of these patients.