Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival
Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival
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DOI：
10.1080/07357900801956363
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Peeters, Marc
中科院分区：
文献类型：
--
作者：
Casneuf, Veerle F.;Fonteyne, Philippe;Peeters, Marc
据报道，许多癌症中葡萄糖转运蛋白的表达增加。目前尚不清楚钠依赖性葡萄糖转运蛋白 1 (SGLT1) 在胰腺癌中是否上调。我们研究了原发性胰腺腺癌中与生存相关的 SGLT1、Bcl-2 和 p53 的表达。在原发性肿瘤中，平均 SGLT1-Hscore (n = 83) 为 4.24（中位数 3.0，范围 0.5-15.0）。 Bcl-2 阳性染色的患者比没有 Bcl-2 表达的患者具有更高的平均 SGLT1-H 分数：5.87 比 3.07（P = 0.025）。 p53 和 SGLT1 的表达之间没有发现相关性（P = 0.881）。多变量分析显示，TNM 分期 (P = 0.015) 和 SGLT1 (P = 0.030) 对无病生存 (DFS) 具有预后价值。对于总生存期 (OS)，TNM 分期 (P0.001) 和化疗 (P = 0.048) 具有预后意义，SGLT1 显示趋势 (P = 0.071)。在未接受化疗的年轻患者亚组（中位年龄 63.9 岁）中，SGLT1 是 DFS 的很强预测因子（P = 0.005）。我们得出的结论是，胰腺腺癌中 SGLT1 的高表达（H 评分中位数为 3.0）与 DFS 显着相关，并且 OS 呈趋势，尤其是在年轻患者中。原发肿瘤中 SGLT1 的高表达与 Bcl-2 的高表达相关，而不是与 p53 的表达相关。这支持了我们的假设，即 SGLT1 和 Bcl-2 表达可以作为胰腺癌的预后标志物。
Increased expression of glucose transporters has been reported in many cancers. It is not known whether Sodium dependent GLucose Transporter 1 (SGLT1) is up-regulated in pancreatic cancer. We studied the expression of SGLT1, Bcl-2 and p53 in primary pancreatic adenocarcinomas related to survival. In primary tumors, mean SGLT1-Hscore (n = 83) was 4.24 (median 3.0, range 0.5-15.0). Patients with positive staining for Bcl-2 had higher mean SGLT1-Hscores than those without Bcl-2 expression: 5.87 vs. 3.07 (P = 0.025). No correlation was found between expression of p53 and SGLT1 (P = 0.881). On multivariate analysis TNM stage (P = 0.015) and SGLT1 (P = 0.030) showed prognostic value for disease free survival (DFS). For overall survival (OS), TNM stage (P0.001) and chemotherapy (P = 0.048) were prognostic and SGLT1 showed a trend (P = 0.071). In a subgroup of younger patients (age median, 63.9 y) who did not receive chemotherapy, SGLT1 was a very strong predictor of DFS (P = 0.005). We conclude that high SGLT1 expression (H score median, 3.0) in pancreatic adenocarcinomas was significantly correlated with DFS and a trend was found for OS, especially in younger patients. High SGLT1 expression in primary tumors was correlated with high Bcl-2 expression, not with p53 expression. This supports our hypothesis that SGLT1 and Bcl-2 expression could serve as prognostic markers in pancreatic cancer.