EUROPEAN SWINE VIRUS AS A POSSIBLE SOURCE FOR THE NEXT INFLUENZA PANDEMIC
EUROPEAN SWINE VIRUS AS A POSSIBLE SOURCE FOR THE NEXT INFLUENZA PANDEMIC
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DOI：
10.1006/viro.1995.1513
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发表时间：
1995-10-01
期刊：
影响因子：
3.7
通讯作者：
SCHOLTISSEK, C
中科院分区：
文献类型：
--
作者：
LUDWIG, S;STITZ, L;SCHOLTISSEK, C
根据系统发育数据，大约100年前，一种禽流感病毒通过了物种障碍(可能是第一次)传给了猪，也可能从那里传给了人类。1979年，一种甲型禽流感病毒(作为一个整体，没有重新分类)再次进入北欧的猪群，形成了一个稳定的谱系。这表明，早期北欧猪病毒的进化速度高于正常，并且在斑块形态和单抗的中和能力方面具有很大的变异性。我们的结果与这样的观点是一致的，即为了通过物种屏障，甲型流感病毒需要一个突变子突变来提供更多的变种，新的宿主可能会从中选择最合适的变种。突变子突变在这样的压力条件下可能是有利的，甚至可能使病毒两次通过整个物种屏障，就像大约100年前发生的那样。对于最近的猪血统来说，这种紧张的局面应该已经结束了，因为病毒似乎已经适应了新的宿主，因为最新的分离株--至少在德国北部--在基因上是稳定的，似乎再次失去了假定的突变子突变。(C)1995年学术出版社。
According to phylogenetic data, about 100 years ago an avian influenza virus passed the species barrier (possibly first) to pigs and (possibly from there) to humans. In 1979 an avian influenza A virus (as a whole, without reassortment) again entered the pig population in northern Europe, forming a stable lineage. Here it is shown that the early North European swine viruses exhibit higher than normal evolutionary rates and are highly variable with respect to plaque morphology and neutralizability by monoclonal antibodies. Our results are consistent with the idea that, in order to pass the species barrier, an influenza A virus needs a mutator mutation to provide an additional number of variants, from which the new host might select the best fitting ones. A mutator mutation could be of advantage under such stress conditions and might enable a virus to pass the species barrier as a whole even twice, as it seems to have happened about 100 years ago. This stressful situation should be over for the recent swine lineage, since the viruses seem to be adapted already to the new host in that the most recent isolates - at least in northern Germany - are genetically stable and seem to have lost the putative mutator mutation again. (C) 1995 Academic Press, Inc.