Reduced neural activity but improved coding in rodent higher-order visual cortex during locomotion.
Reduced neural activity but improved coding in rodent higher-order visual cortex during locomotion.
复制标题
减少神经活动，但改善啮齿动物运动过程中高阶视觉皮层的编码。
DOI：
10.1038/s41467-022-29200-z
复制
发表时间：
2022-03-30
影响因子：
16.6
通讯作者：
Pillow JW
中科院分区：
文献类型：
--
作者：
Christensen AJ;Pillow JW
跑步深刻地改变了小鼠初级视觉皮层（V1）的刺激-反应特性，但其在高阶视觉皮层的影响尚未得到充分研究。在这里，我们系统地研究了视觉反应如何在六个视觉区域和三个皮质层使用来自艾伦脑研究所的大量数据集的运动状态的变化。虽然之前的研究表明，跑步速度与V1区的神经活动呈正相关，但在这里，我们发现，速度与神经活动之间的相关性在纹外皮层中各不相同，甚至在前纹外皮层中为负相关。然而，在所有的视觉皮层中，跑步期间的神经反应比静止期间更准确。我们表明，这种影响是不归因于人口活动结构的变化，并提出它反而产生于运动过程中的单神经元反应的可靠性增加。作者分析了艾伦研究所脑观察站Ca 2+成像数据，重点是运动和静止状态下的小鼠视觉皮层。他们发现，运动增加了神经编码的保真度，而不管群体活动是否因群体偏好的刺激而增加或减少。
Running profoundly alters stimulus-response properties in mouse primary visual cortex (V1), but its effect in higher-order visual cortex is under-explored. Here we systematically investigate how visual responses vary with locomotive state across six visual areas and three cortical layers using a massive dataset from the Allen Brain Institute. Although previous work has shown running speed to be positively correlated with neural activity in V1, here we show that the sign of correlations between speed and neural activity varies across extra-striate cortex, and is even negative in anterior extra-striate cortex. Nevertheless, across all visual cortices, neural responses can be decoded more accurately during running than during stationary periods. We show that this effect is not attributable to changes in population activity structure, and propose that it instead arises from an increase in reliability of single-neuron responses during locomotion. The authors analyze the Allen Institute Brain Observatory Ca2+ imaging data, focusing on mouse visual cortex during locomotive and quiescent states. They find that locomotion increases neural coding fidelity, regardless of whether population activity increases or decreases in response to the population’s preferred stimuli.