Two new α-Methoxy-γ-Pyrones From the Mangrove Sediment-Derived Streptomyces psammoticus SCSIO NS126
Two new α-Methoxy-γ-Pyrones From the Mangrove Sediment-Derived Streptomyces psammoticus SCSIO NS126
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DOI：
10.1177/1934578x211041420
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发表时间：
2021-09
影响因子：
1.8
通讯作者：
Kunlong Li;Mengdie Zhou;Ziqi Su;Xiliang Yang;Xuefeng Zhou;Jingxia Huang;Huaming Tao
中科院分区：
文献类型：
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作者：
Kunlong Li;Mengdie Zhou;Ziqi Su;Xiliang Yang;Xuefeng Zhou;Jingxia Huang;Huaming Tao
在优化的发酵条件下，从红树林底泥来源放线菌菌株α-Ac-Ac的提取液中分离得到两个新的2-甲氧基-3-甲基-5，6-二乙基-γ-吡喃酮(2)和2-甲氧基-3，5-二甲基-6-丙基-γ-吡喃酮(3)和2-甲氧基-3，5-二甲基-6-乙基-γ-吡喃酮(1)。通过详细的光谱分析和与文献报道的光谱数据的比较，确定了它们的结构。对α-甲氧基-γ-吡喃类化合物的乙酰胆碱酯酶抑制活性进行了评价，但没有一种化合物表现出明显的活性。此外，还讨论了它们与青霉毒素的生物合成关系。
Two new α-methoxy-γ-pyrone analogs, 2-methoxy-3-methyl-5,6-diethyl-γ-pyrone (2) and 2-methoxy-3,5-dimethyl-6-propyl-γ-pyrone (3), together with 2-methoxy-3,5-dimethyl-6-ethyl-γ-pyrone (1), firstly isolated from natural sources, were obtained from the EtOAc-solube extract of the mangrove sediment-derived actinomycete strain Streptomyces psammoticus SCSIO NS126, under the optimized fermentation conditions. Their structures were elucidated by detailed spectroscopic analysis and by comparison of their spectroscopic data with those reported in the literature. Those α-methoxy-γ-pyrones were evaluated for their acetylcholinesterase inhibitory activity; however, none of them exhibited obvious activity. Moreover, their biosynthetic relationship with piericidins was also discussed.