Serum hematopoietic growth factors as diagnostic and prognostic markers of acute renal allograft rejection: a potential role for serum stem cell factor.
Serum hematopoietic growth factors as diagnostic and prognostic markers of acute renal allograft rejection: a potential role for serum stem cell factor.
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DOI：
10.1016/j.cyto.2011.09.011
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发表时间：
2011-12
期刊：
影响因子：
3.8
通讯作者：
Xiao-guang Xu;Haiyan Huang;M. Cai;Y. Qian;Yong Han;L. Xiao;Wen-qiang Zhou;Xinying Wang;B. Shi
中科院分区：
文献类型：
--
作者：
Xiao-guang Xu;Haiyan Huang;M. Cai;Y. Qian;Yong Han;L. Xiao;Wen-qiang Zhou;Xinying Wang;B. Shi
造血生长因子（HGFs）是造血干细胞的增殖和趋化因子，但其在肾移植中的作用报道很少。为探讨HGFs与急性T细胞介导的肾移植排斥反应的关系，采用EXPERIMENTARY GNA细胞因子微球芯片检测了32例急性T细胞介导的肾移植排斥反应患者排斥反应前、排斥反应中及排斥反应逆转后血清中10种HGFs的含量。结果：排斥反应发生时，血清干细胞因子（SCF）、IL-3、flt 3配体、G-CSF、M-CSF和GM-CSF水平均较排斥反应前和排斥反应后升高。SCF、G-CSF、flt 3配体和IL-3的血清浓度显著高于无排斥反应时。此外，血清SCF水平显着较高的患者排斥反应前与稳定controls.CONCLUSIONSHGFs报道参与急性T细胞介导的肾移植排斥反应。SCF水平与急性肾移植排斥反应的发生直接相关，这可能是急性细胞性肾移植排斥反应的有效诊断和预测生物标志物。
OBJECTIVESHematopoietic growth factors (HGFs) are proliferative and chemotactic agents for hematopoietic stem cells, although their functions on renal transplantation are rarely reported. This study aimed to investigate the association of HGFs with acute T cell-mediated renal rejection.EXPERIMENTAL DESIGNA cytokine bead array was used to analyze 10 HGFs in the sera of 32 patients with acute T cell-mediated renal allograft rejection before and during rejection and after rejection reversal. Stable renal allograft recipients (n=38) were also investigated.RESULTSSerum levels of stem cell factor (SCF), IL-3, flt3 ligand, G-CSF, M-CSF and GM-CSF were elevated during episodes of rejection compared with before and after rejection. Serum concentrations of SCF, G-CSF, flt3 ligand and IL-3 were significantly higher than in the absence of rejection. Moreover, serum SCF levels were significantly higher in patients before rejection versus stable controls.CONCLUSIONSHGFs are reported to be involved in acute T cell-mediated renal allograft rejection. A direct correlation was observed between SCF levels and the occurrence of acute renal allograft rejection which may represent an effective diagnostic and predictive biomarker for acute cellular renal allograft rejection.