Langerhans Cells: Sensing the Environment in Health and Disease.
Langerhans Cells: Sensing the Environment in Health and Disease.
复制标题
DOI：
10.3389/fimmu.2018.00093
复制
发表时间：
2018
影响因子：
7.3
通讯作者：
Hoste E
中科院分区：
文献类型：
--
作者：
Deckers J;Hammad H;Hoste E
在过去几十年中，基于有关这些表皮特异性常驻免疫细胞的发育起源和生物学功能的新发现，我们对朗格汉斯细胞（LCs）的认识发生了巨大变化。已经明确的是，朗格汉斯细胞不仅在免疫监视和内稳态中发挥关键作用，而且还通过诱导耐受或介导炎症影响病理过程。它们在表皮内自我更新的独特能力，以及能够迁移到淋巴结以呈递抗原的能力，使朗格汉斯细胞处于对局部环境进行取样并决定适当的皮肤免疫反应的关键位置。在功能和个体发生水平上区分朗格汉斯细胞与朗格素阳性真皮树突状细胞（DCs）的令人兴奋的新数据揭示了朗格汉斯细胞在创伤和各种皮肤病理中的关键作用，这将在此进行深入讨论。然而，尽管该领域进展迅速，但朗格汉斯细胞在免疫反应过程中的确切作用尚未完全阐明。这篇综述重点关注为了能够研究小鼠朗格汉斯细胞和其他表达朗格素的树突状细胞而开发的小鼠模型，这些模型让我们对朗格汉斯细胞的发育和功能有了哪些了解。
In the last few decades, our understanding of Langerhans cells (LCs) has drastically changed based on novel findings regarding the developmental origin and biological functions of these epidermis-specific resident immune cells. It has become clear that LCs not only exert pivotal roles in immune surveillance and homeostasis but also impact on pathology by either inducing tolerance or mediating inflammation. Their unique capabilities to self-renew within the epidermis, while also being able to migrate to lymph nodes in order to present antigen, place LCs in a key position to sample the local environment and decide on the appropriate cutaneous immune response. Exciting new data distinguishing LCs from Langerin+ dermal dendritic cells (DCs) on a functional and ontogenic level reveal crucial roles for LCs in trauma and various skin pathologies, which will be thoroughly discussed here. However, despite rapid progress in the field, the exact role of LCs during immune responses has not been completely elucidated. This review focuses on what mouse models that have been developed in order to enable the study of murine LCs and other Langerin-expressing DCs have taught us about LC development and function.
登录
查看更多内容
Langerhans细胞（LC）增殖介导了新生儿发育，体内平衡和与表皮LC网络的炎症相关扩张。
DOI：
10.1084/jem.20091586
发表时间：
2009-12-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chorro L;Sarde A;Li M;Woollard KJ;Chambon P;Malissen B;Kissenpfennig A;Barbaroux JB;Groves R;Geissmann F
通讯作者：
Geissmann F
影响因子：
28.2
作者：
Diamond EL;Durham BH;Haroche J;Yao Z;Ma J;Parikh SA;Wang Z;Choi J;Kim E;Cohen-Aubart F;Lee SC;Gao Y;Micol JB;Campbell P;Walsh MP;Sylvester B;Dolgalev I;Aminova O;Heguy A;Zappile P;Nakitandwe J;Ganzel C;Dalton JD;Ellison DW;Estrada-Veras J;Lacouture M;Gahl WA;Stephens PJ;Miller VA;Ross JS;Ali SM;Briggs SR;Fasan O;Block J;Héritier S;Donadieu J;Solit DB;Hyman DM;Baselga J;Janku F;Taylor BS;Park CY;Amoura Z;Dogan A;Emile JF;Rosen N;Gruber TA;Abdel-Wahab O
通讯作者：
Abdel-Wahab O
影响因子：
50.3
作者：
Demehri, Shadmehr;Turkoz, Ahu;Kopan, Raphael
通讯作者：
Kopan, Raphael
影响因子：
20.3
作者：
Badalian-Very, Gayane;Vergilio, Jo-Anne;Rollins, Barrett J.
通讯作者：
Rollins, Barrett J.
表皮屏障缺陷将特应性皮炎与皮肤癌敏感性改变。
影响因子：
7.7
作者：
Cipolat S;Hoste E;Natsuga K;Quist SR;Watt FM
通讯作者：
Watt FM