Noncomparability of longitudinally and cross-sectionally determined annual change in spirometry.
Noncomparability of longitudinally and cross-sectionally determined annual change in spirometry.
复制标题
纵向和横向确定的肺活量测定年度变化的不可比性。
DOI：
10.1164/arrd.1982.125.5.544
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Weill,H
中科院分区：
文献类型：
--
作者：
Glindmeyer,HW;Diem,JE;Jones,RN;Weill,H
纵向测定的肺功能年下降常常与横截面测定的预测下降进行比较。为了测试这种比较，肺量测定数据收集了5次，超过5年，从52名成年男性高加索人。在每次访视时横断面测定的FEV1和FVC的年龄回归系数是根据与每个受试者回归线斜率平均值相同的数据计算的纵向年变化的两倍以上。即使删除了第一次访问，以减少纵向估计的学习效果，这种差异仍然存在。这种差异可能部分解释的敏感性横截面分析过去的有害影响，而纵向分析只敏感的影响，继续影响在研究期间每年下降。我们还发现了历史证据的高度特定VC的增加，这将人为地陡峭的横截面确定的回归线。因此，应将观察到的研究队列的纵向变化与对照纵向数据进行比较。
Annual decline in lung function determined longitudinally is often compared with predicted decline determined cross-sectionally. To test this comparison, spirometric data were collected 5 times over 5 yr from 52 adult male Caucasians. The age regression coefficient for FEV1and FVC, determined cross-sectionally at each visit, was more than twice the longitudinal annual change computed from the same data as the mean of the slopes of each subject’s regression lines. The discrepancy persisted even when the first visit was deleted to reduce learning effects on longitudinal estimates. This discrepancy may be partly explained by the sensitivity of cross-sectional analyses to past noxious influences, whereas longitudinal analyses are sensitive only to influences that continue to affect annual decline during the study period. We also found historical evidence of an increase in height-specific VC, which would artifactually steepen crosssectionally determined regression lines. Thus, observed longitudinal changes of study cohorts should be compared with control longitudinal data.