Extraocular muscles have fundamentally distinct properties that make them selectively vulnerable to certain disorders
Extraocular muscles have fundamentally distinct properties that make them selectively vulnerable to certain disorders
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DOI：
10.1016/j.nmd.2004.10.002
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发表时间：
2005-01-01
影响因子：
2.8
通讯作者：
Griffiths, PG
中科院分区：
文献类型：
--
作者：
Yu, CY;Man, W;Griffiths, PG
虽然骨骼肌通常扮演着特定的有限角色，但眼外肌(EOMS)必须在更大的动态范围内做出反应。因此，与其他骨骼肌相比，EOMS具有根本不同的结构、功能、生化和免疫学特性。虽然这些特性能够实现高抗疲劳性和快速而精确的眼外运动控制，但它们也可能解释为什么EOMS选择性地参与某些疾病。如慢性进行性眼外肌麻痹(CPEO)、重症肌无力和Graves眼病。这篇综述首先概述了EOMS中肌纤维的新分类，然后重点介绍了那些可能解释为什么眼肌麻痹在这些疾病中如此突出的特性。(C)2004爱思唯尔B.V.保留所有权利。
While skeletal muscles generally perform specific limited roles, extraocular muscles (EOMs) have to be responsive over a wider dynamic range. As a result, EOMs have fundamentally distinct structural, functional, biochemical and immunological properties compared to other skeletal muscles. While these properties enable high fatigue resistance and the rapid and precise control of extraocular motility, they might also explain why EOMs are selectively involved in certain disorders. such as chronic progressive external ophthalmoplegia (CPEO), myasthenia gravis and Graves' ophthalmopathy. This review first gives an overview of the novel myofibre classification in EOMs and then focuses on those properties that might explain why ophthalmoplegia should be so prominent in these disorders. (C) 2004 Elsevier B.V. All rights reserved.