Reprint of: Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood.
Reprint of: Internalising symptoms mediate the longitudinal association between childhood inflammation and psychotic-like experiences in adulthood.
复制标题
转载：内化症状介导儿童期炎症与成年期精神病样经历之间的纵向关联。
DOI：
10.1016/j.schres.2020.11.009
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发表时间：
2020
影响因子：
4.5
通讯作者：
Francesconi M
中科院分区：
文献类型：
--
作者：
Francesconi M
类精神病经历(PLE)是精神病连续体的一部分。先前的纵向研究强调了儿童时期的外周炎症和成年后PLES的发病之间的关系。在这项研究中，我们测试了这种联系是否通过儿童和青春期经历的内化和外化症状来调节。为了验证这一假设，我们使用了雅芳亲子纵向研究(ALSPAC)的数据。我们调查了该队列中4,525名儿童(9岁 )的白介素6(IL-6)和C反应蛋白(C反应蛋白)。我们在18 岁时测量了PLE，并使用潜在生长曲线模型来估计9至16 岁内化和外化症状的纵向轨迹。然后将截距(设定在基线，9 年)和斜率(年变化率)的个人预测值用于中介分析。有证据表明，完全可以通过截获内化症状来进行调解。我们的发现表明，儿童时期的炎症可能通过与高水平的内化症状有关而与未来的PLES发病有关。这些发现，虽然是从非临床人群中获得的，但在推进关于炎症和精神疾病连续体症状之间关系的知识方面提供了额外的步骤。
Psychotic-like experiences (PLEs) are part of a continuum of psychosis. Previous longitudinal studies highlighted a relationship between peripheral inflammation during childhood and onset of PLEs in adulthood. In this study, we tested if this association is mediated by internalising and externalising symptoms experienced during childhood and adolescence. To test this hypothesis, we used data from the Avon Longitudinal Study of Parents and Children (ALSPAC). We investigated a subsample of 4525 individuals from this cohort with data on interleukin 6 (IL-6) and C-reactive protein (CRP) in childhood (age 9 years). We measured PLEs at age 18 years, and we used latent growth curve modelling to estimate longitudinal trajectories of internalising and externalising symptoms from ages 9 to 16 years. The individual predicted values of the intercept (set at baseline, 9 years) and the slope (rate of annual change) were then used in the mediation analysis. There was evidence for full mediation by the intercept of internalising symptoms. Our findings suggest that inflammation during childhood may be relevant for the future onset of PLEs via its association with a high level of internalising symptoms. These findings, although obtained from a non-clinical population, provide an additional step in advancing knowledge on the relationship between inflammation and symptoms of the psychosis continuum.