Prospective study of calcium, potassium, and magnesium intake and risk of stroke in women
Prospective study of calcium, potassium, and magnesium intake and risk of stroke in women
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DOI：
10.1161/01.str.30.9.1772
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发表时间：
1999-09-01
期刊：
影响因子：
8.3
通讯作者：
Willett, WC
中科院分区：
文献类型：
--
作者：
Iso, H;Stampfer, MJ;Willett, WC
背景和目的--高钙、钾和镁的摄入量被认为可以降低心血管疾病的风险，但是只有少数前瞻性研究检测了这些阳离子的摄入量与中风风险的关系。方法--在1980年，85764名年龄在34到59岁之间，没有被诊断为心血管疾病和癌症的女性参加了护士健康研究队列，完成饮食调查问卷，计算钙、钾和镁的摄入量。到1994年，经过116万人年的随访，（129例蛛网膜下腔出血，74例脑实质内出血，386例缺血性中风，101例未确定类型的中风）。结果-钙、钾和镁的摄入量分别与年龄和吸烟调整的缺血性中风的相对风险呈负相关，排除非动脉粥样硬化性栓塞性梗死（n=347），调整其他心血管危险因素，包括高血压史，减弱了这些相关性，特别是镁摄入量。在多变量分析中，钙摄入量最高五分位数的女性与最低五分位数的女性相比，缺血性卒中的校正相对风险为0.69（95%CI，0.50至0.95;趋势P =0.03）;钾摄入量相应的相对风险为0.72（95%CI，0.51至1.01;趋势P =0.10）。进一步同时调整钙和钾的摄入量，提示钙摄入量与中风风险之间存在独立的相关性。钙摄入量与中风风险之间的相关性似乎不是对数线性的;风险的增加仅限于摄入量的最低五分位数，摄入量> 600 mg/d似乎不能进一步降低中风风险。与钙摄入量的负相关性更强的乳制品比非乳制品钙摄入量。钙，钾，镁的摄入量与其他中风subtype. Conclusions的风险低钙的摄入量，也许低钾的摄入量，可能有助于增加中年美国妇女缺血性中风的风险。钙摄入量最低的五分之一的妇女仍有可能具有未知的特征，使她们易患缺血性中风。
Background and Purpose-High intakes of calcium, potassium, and magnesium have been hypothesized to reduce risks of cardiovascular disease, but only a few prospective studies have examined intakes of these cations in relation to risk of stroke.Methods-In 1980, 85 764 women in the Nurses' Health Study cohort, aged 34 to 59 years and free of diagnosed cardiovascular disease and cancer, completed dietary questionnaires from which we calculated intakes of calcium, potassium, and magnesium. By 1994, after 1.16 million person-years of follow-up, 690 incident strokes (129 subarachnoid hemorrhages, 74 intraparenchymal hemorrhages, 386 ischemic strokes, and 101 strokes of undetermined type) had been documented.Results-Intakes of calcium, potassium, and magnesium were each inversely associated with age- and smoking-adjusted relative risks of ischemic stroke, excluding embolic infarction of nonatherogenic origin (n=347), Adjustment for other cardiovascular risk factors, including history of hypertension, attenuated these associations, particularly for magnesium intake. In a multivariate analysis, women in the highest quintile of calcium intake had an adjusted relative risk of ischemic stroke of 0.69 (95% CI, 0.50 to 0.95; P for trend=0.03) compared with those in the lowest quintile; for potassium intake the corresponding relative risk was 0.72 (95% CI, 0.51 to 1.01; P for trend=0.10). Further simultaneous adjustment for calcium and potassium intake suggested an independent association for calcium intake, The association of risk with calcium intake did not appear to be log linear; the increase in risk was limited to the lowest quintile of intake, and intakes >approximate to 600 mg/d did not appear to reduce risk of stroke further. The inverse association with calcium intake was stronger for dairy than for nondairy calcium intake. Intakes of calcium, potassium, and magnesium were not related to risk of other stroke subtypes.Conclusions-Low calcium intake, and perhaps low potassium intake, may contribute to increased risk of ischemic stroke in middle-aged American women. It remains possible that women in the lowest quintile of calcium intake had unknown characteristics that made them susceptible to ischemic stroke.