Oral vaccination with different antigens from Yersinia pestis KIM delivered by live attenuated Salmonella typhimurium elicits a protective immune response against plague.
Oral vaccination with different antigens from Yersinia pestis KIM delivered by live attenuated Salmonella typhimurium elicits a protective immune response against plague.
复制标题
口服疫苗接种鼠疫耶尔森氏菌 KIM 的不同抗原（由减毒活鼠伤寒沙门氏菌传递），可引发针对鼠疫的保护性免疫反应。
DOI：
10.1007/978-0-387-72124-8_36
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发表时间：
2007
影响因子：
--
通讯作者：
Curtiss3rd,Roy
中科院分区：
文献类型：
--
作者：
Branger,ChristineG;Fetherston,JacquelineD;Perry,RobertD;Curtiss3rd,Roy
The use of live recombinantSalmonellaattenuated vaccine (RASV) encodingYersiniaproteins is a promising new approach for the vaccination againstYersinia pestis.We have tested the efficacy of 2 proteins, Psn and a portion of LcrV in protecting mice against virulentYersinia pestischallenge. To remove the immunosuppressive properties of LcrV protein, thelcrVgene, without the TLR2 receptor sequence, was cloned into a β-lactamase secretion vector. Immunizations were performed with RSAV expressing LcrV or Psn. Challenge with a virulentY. pestisstrain was performed 4 weeks after the last immunization. Our results show that the truncated LcrV protein delivered by RASV is sufficient to afford a full protective immune response in a mouse model of bubonic plague and the Psn protein afforded partial protection in a non-optimized system. This finding should facilitate the design and development of a new generation of vaccines againstY. pestis.
