Mapping clinically relevant plasticity after stroke
Mapping clinically relevant plasticity after stroke
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DOI：
10.1016/s0028-3908(99)00258-0
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发表时间：
2000-01-01
影响因子：
4.7
通讯作者：
Bastings, EP
中科院分区：
文献类型：
--
作者：
Cramer, SC;Bastings, EP
中风后，患者表现出不同程度的恢复。恢复发生在离散的生理事件的基础上。识别和测量这些事件将有助于更好地理解中风恢复机制。最广泛的经验映射这些事件已经与正电子发射断层扫描，功能磁共振成像，经颅磁刺激。本文回顾了脑地形图研究，检查中风恢复。在恢复期对患者进行系列评估，需要进行对照研究，以评估受试者内变异性随时间的影响。对中风影响的手在单侧运动期间双侧激活的意义的最清晰的见解将来自包括双侧肌电图测量的研究。大多数脑成像研究都集中在恢复非常好的患者身上;需要对具有广泛结局的患者进行进一步研究。所描述的脑映射方法具有互补的优势。当综合考虑结果时，可能最好能深入了解恢复的生物学基础。随着针对中风恢复的治疗的出现，中风后恢复性事件的测量也可能具有作为临床试验中的替代终点的价值。(C)2000爱思唯尔科技有限公司版权所有。
After stroke, patients show a wide range in the degree of recovery. Recovery occurs on the basis of discrete physiologic events. Identifying and measuring these events will be useful for a better understanding of stroke recovery mechanisms. The most extensive experience mapping these events has been with positron emission tomography, functional magnetic resonance imaging, and transcranial magnetic stimulation. This article reviews brain mapping studies that have examined stroke recovery. Serial assessment of patients during recovery raises the need for control studies evaluating the effect of intra-subject variability over time. The clearest insights into the significance of bilateral activation during unilateral movements by the stroke-affected hand will come from studies that include bilateral electromyographic measurements. Most brain imaging studies have focused on patients with very good recovery; further study of patients with a wide range of outcomes is needed. The described brain mapping methods have complementary strengths. Insights into the biological basis: of recovery may best be achieved when results are considered together. With the advent of treatments targeting stroke recovery, measurement of post-stroke restorative events may also have value as a surrogate end point in clinical trials. (C) 2000 Elsevier Science Ltd. All rights reserved.