EFFICACY AND SAFETY OF ALBENDAZOLE AGAINST EXPERIMENTALLY INDUCED FASCIOLA-HEPATICA INFECTIONS IN GOATS
EFFICACY AND SAFETY OF ALBENDAZOLE AGAINST EXPERIMENTALLY INDUCED FASCIOLA-HEPATICA INFECTIONS IN GOATS
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DOI：
10.1016/0304-4017(88)90094-5
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发表时间：
1988-01-01
影响因子：
2.6
通讯作者：
FOREYT, WJ
中科院分区：
文献类型：
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作者：
FOREYT, WJ
将 40 只 8 周龄山羊分为大小相等的 5 组，以确定阿苯达唑针对实验诱导的 14 周龄肝片形吸虫感染的最佳剂量。与未治疗的对照相比，口服5.0、7.5、10.0和15 mg kg-1体重的阿苯达唑混悬液的有效率分别为73.3、88.2、88.3和95.9%。未经处理的对照山羊中肝镰刀菌的平均数量为 75.4。没有观察到毒性迹象。当给八只 8 周龄山羊口服阿苯达唑 75 mg kg-1（最佳剂量的五倍）时，没有观察到毒性迹象。
Forty 8-week-old goats were allocated to five groups of equal size to determine the optimal dosage of albendazole against experimentally induced 14-week-old Fasciola hepatica infections. Albendazole suspension given orally at 5.0, 7.5, 10.0 ad 15 mg kg-1 of body weight was 73.3, 88.2, 88.3 and 95.9% effective, respectively, when compared to untreated controls. Mean number of F. hepatica in the untreated control goats was 75.4. No signs of toxicity were observed. When albendazole was given to eight, 8-week-old goats orally at 75 mg kg-1 (five times the optimal dosage), no signs of toxicity were observed.