Bacterial communication through membrane vesicles
Bacterial communication through membrane vesicles
复制标题
DOI：
10.1080/09168451.2019.1608809
复制
发表时间：
2019-04
期刊：
影响因子：
--
通讯作者：
M. Toyofuku
中科院分区：
文献类型：
--
作者：
M. Toyofuku
细菌可以通过由同源受体感知的可扩散信号分子进行通信。现在已经很好地确定，细菌通讯调节数百个基因。在细菌通讯中已经鉴定出在水性环境中不单独扩散的疏水分子，这提出了关于这些分子如何在细胞之间运输并触发基因表达的问题。最近的研究表明，这些疏水信号分子，包括长链N-酰基高丝氨酸内酯信号产生的副球菌，是由膜囊泡（MV）。MVs被认为仅通过细胞膜的起泡形成，但在铜绿假单胞菌和枯草芽孢杆菌中的新发现表明，不同类型的MVs可以通过爆炸性细胞溶解或起泡细胞死亡形成，这些发现对我们对细菌相互作用的看法有一定的影响。图像显示了通过冷冻电子断层扫描分析的枯草芽孢杆菌细胞中气泡细胞死亡形成MV的模型15。
ABSTRACT Bacteria can communicate through diffusible signaling molecules that are perceived by cognate receptors. It is now well established that bacterial communication regulates hundreds of genes. Hydrophobic molecules which do not diffuse in aqueous environments alone have been identified in bacterial communication, that raised the question on how these molecules are transported between cells and trigger gene expressions. Recent studies show that these hydrophobic signaling molecules, including a long-chain N-acyl homoserine lactone signal produced in Paracoccus denitrificans, are carried by membrane vesicles (MVs). MVs were thought to be formed only through the blebbing of the cell membrane, but new findings in Pseudomonas aeruginosa and Bacillus subtilis revealed that different types of MVs can be formed through explosive cell lysis or bubbling cell death, which findings have certain implications on our view of bacterial interactions. Graphic abstract The image shows a model of MV formation through bubbling cell death in a Bacillus subtilis cell analyzed by cryo-electron tomography15.