Trauma-focused cognitive behaviour therapy versus treatment as usual for post traumatic stress disorder (PTSD) in young children aged 3 to 8 years: study protocol for a randomised controlled trial.
Trauma-focused cognitive behaviour therapy versus treatment as usual for post traumatic stress disorder (PTSD) in young children aged 3 to 8 years: study protocol for a randomised controlled trial.
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DOI：
10.1186/s13063-015-0632-2
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发表时间：
2015-03-25
期刊：
影响因子：
2.5
通讯作者：
Meiser-Stedman R
中科院分区：
文献类型：
--
作者：
Dalgleish T;Goodall B;Chadwick I;Werner-Seidler A;McKinnon A;Morant N;Schweizer S;Panesar I;Humphrey A;Watson P;Lafortune L;Smith P;Meiser-Stedman R
在发生可怕或危及生命的事件后，大约10%至15%的幼儿会患上创伤后应激障碍(PTSD)。这种疾病的症状是令人痛苦的--噩梦、闪回、愤怒的爆发和扰乱的游戏。这些症状会对儿童的功能造成严重干扰，如果不加以治疗，可能会持续多年。到目前为止，还没有建立起经验性的治疗幼儿创伤后应激障碍的方法。以创伤为重点的认知行为疗法(TF-CBT)是一种心理干预，对年龄较大的儿童(8至12岁)、青少年和成年人有效。这项研究考察了适用于3至8岁儿童的TF-CBT。该方案描述了一项双臂探索性随机对照试验，将TF-CBT与常规治疗(TAU)进行比较，研究对象为3至8岁的儿童，主要诊断为单一事件离散创伤后的创伤后应激障碍。采用半交叉设计，44名参与者将被随机分配接受干预或接受TAU。分配给TAU的患者如果仍有适应症，将在‘治疗’期(约12周)结束时提供TF-CBT。主要结果是根据治疗后6岁及以下儿童的DSM-5标准诊断为创伤后应激障碍。次要结果包括在每个随访点(治疗后、3个月、12个月)对共病诊断的影响以及情绪和创伤症状的变化。此外，还将考虑更广泛的疗效，包括治疗的可行性、可接受性和服务利用率。干预的主要目标是创伤记忆、事件意义的解释和症状的管理。这是第一个检验TF-CBT在缓解幼儿创伤后应激障碍疗效的欧洲试验。除了提供有关干预效用的迫切需要的数据外，这项探索性试验还将使我们能够收集有关在英国国民医疗服务(NHS)环境下提供治疗的可行性以及儿童及其家庭可接受程度的重要信息。这项研究将突出干预措施中需要改进或修改的方面，为在更大样本中进行全面评估做准备。ISRCTN35018680,2013年11月18日注册。
Following horrific or life-threatening events approximately 10 to 15% of young children develop post traumatic stress disorder (PTSD). The symptoms of this disorder are distressing - nightmares, flashbacks, anger outbursts and disturbed play. These symptoms cause major disruption to a child’s functioning and, if left untreated, can persist for many years. As yet, there are no established empirically-validated treatments for PTSD in young children. Trauma-focused cognitive behaviour therapy (TF-CBT) is a psychological intervention that is effective in treating the disorder in older children (8 to 12 years), adolescents and adults. This study examines TF-CBT adapted for children aged between 3 and 8 years. This protocol describes a two-arm exploratory randomised controlled trial comparing TF-CBT to treatment as usual (TAU) in children aged 3 to 8 years with a principal diagnosis of PTSD following a single-event discrete trauma. Using a half-crossover design, 44 participants will be randomly allocated to receive the intervention or to receive TAU. Those allocated to TAU will be offered TF-CBT at the end of the ‘treatment’ period (approximately 12 weeks) if still indicated. The primary outcome is PTSD diagnosis according to DSM-5 criteria for children 6 years and younger at post-treatment. Secondary outcomes include effects on co-morbid diagnoses and changes in emotion and trauma symptoms at each of the follow-up points (post-treatment, 3-months, 12-months). Additionally, broader efficacy will be considered with regard to treatment feasibility, acceptability and service utilisation. The key targets of the intervention are trauma memory, the interpretation of the meaning of the event, and the management of symptoms. This is the first European trial to examine the efficacy of TF-CBT in alleviating PTSD in very young children. As well as providing much-needed data on the utility of the intervention, this exploratory trial will also allow us to gather important information about the feasibility of delivering the treatment in UK National Health Service (NHS) settings, and its acceptability to the children and their families. This study will highlight aspects of the intervention that need improvement or modification in preparation for a full-scale evaluation in a larger sample. ISRCTN35018680, registered on 18 November 2013.
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DOI：
10.1097/01.chi.0000046822.95464.14
发表时间：
2003-05-01
影响因子：
13.3
作者：
Scheeringa, M;Zeanah, CH;Putnam, FW
通讯作者：
Putnam, FW
影响因子：
--
作者：
Copeland, William E.;Keeler, Gordon;Costello, E. Jane
通讯作者：
Costello, E. Jane
DOI：
10.1207/s15374424jccp2801_6
发表时间：
1999-03-01
期刊：
JOURNAL OF CLINICAL CHILD PSYCHOLOGY
影响因子：
--
作者：
Saylor, CF;Swenson, CC;Taylor, M
通讯作者：
Taylor, M
影响因子：
7.4
作者：
Scheeringa MS;Zeanah CH;Cohen JA
通讯作者：
Cohen JA
DOI：
10.1207/s15374424jccp3003_9
发表时间：
2001-09-01
期刊：
JOURNAL OF CLINICAL CHILD PSYCHOLOGY
影响因子：
--
作者：
Foa, EB;Johnson, KM;Treadwell, KRH
通讯作者：
Treadwell, KRH