Relationship between bone mineral density and myocardial infarction in US adults
Relationship between bone mineral density and myocardial infarction in US adults
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DOI：
10.1007/s00198-005-1999-9
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发表时间：
2005-12-01
影响因子：
4
通讯作者：
Broussard, DL
中科院分区：
文献类型：
--
作者：
Magnus, JH;Broussard, DL
心血管疾病和骨质疏松症有几个常见的危险因素，相当多的研究表明它们之间存在关系。本研究的目的是探讨普通人群中心血管疾病危险因素和骨矿物质密度与既往心肌梗塞史之间的关系。这项横断面研究使用了参加第三次全国健康和营养检查调查 (NHANES III) 的 5,050 名 50-79 岁女性和男性的数据。年轻人的种族/民族和性别特定平均 BMD 值用于确定种族/民族和性别特定 T 分数，以定义骨质疏松症和低 BMD。多元逻辑回归分析显示，在调整心血管疾病和骨质疏松症危险因素时，自我报告既往心肌梗塞的受试者骨密度低的几率显着较高（比值比 1.28，[95% 置信区间 (CI)，1.01 至 1.63] p = 0.04）。女性自我报告的心肌梗死与低骨密度无关（比值比 1.22，[95% CI，0.80 至 1.86] p = 0.37），但在男性中显着相关（比值比 1.39，[95% CI，1.03 至 1.87] p = 0.03）。这些发现表明，心肌梗塞的男性幸存者骨矿物质密度较低。动脉粥样硬化和骨质疏松过程之间的病理生理学联系需要进一步阐明。研究男性和女性的这一过程也很重要。
Cardiovascular disease and osteoporosis have several common risk factors, and quite a few studies suggest a relationship between them. The objective of the present study was to explore the relationship between cardiovascular disease risk factors and bone mineral density in association with having had a previous myocardial infarction in a general population. This cross-sectional study was conducted using data for 5,050 women and men aged 50-79 years who participated in the Third National Health and Nutrition Examination Survey (NHANES III). Race/ethnic and gender-specific mean BMD values for young adults were used to determine race/ethnic and gender-specific T -scores to define osteoporosis and low BMD. Multiple logistic regression analysis revealed that subjects self-reporting a previous myocardial infarction had significantly higher odds (odds ratio 1.28, [95% confidence interval (CI), 1.01 to 1.63] p =0.04) of having low bone mineral density, when adjusting for cardiovascular disease and osteoporosis risk factors. Self-reported myocardial infarction was not significantly associated with low bone mineral density in women, (odds ratio 1.22, [95% CI, 0.80 to 1.86] p =0.37), but was significant in men, (odds ratio 1.39, [95% CI, 1.03 to 1.87] p =0.03). These findings demonstrate that male survivors of myocardial infarction have low bone mineral density. The pathophysiologic connection between the atherosclerotic and the osteoporotic processes needs further elucidation. It is also of importance to study the processes in both men and women.