Dietary fiber intake and risk of incident disabling dementia: the Circulatory Risk in Communities Study
Dietary fiber intake and risk of incident disabling dementia: the Circulatory Risk in Communities Study
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膳食纤维摄入量与致残性痴呆事件的风险：社区循环风险研究
DOI：
10.1080/1028415x.2022.2027592
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Iso H
中科院分区：
文献类型：
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作者：
Yamagishi K;Maruyama K;Ikeda A;Nagao M;Noda H;Umesawa U;Hayama-Terada M;Muraki I;Okada C;Tanaka M;Kishida R;Kihara T;Ohira T;Imano H;Brunner EJ;Sankai T;Okada T;Tanigawa T;Kitamura A;Kiyama M;Iso H
目的膳食纤维摄入对预防痴呆有有益影响的假设，但流行病学证据不足。我们试图研究膳食纤维摄入量是否与国民保险下需要护理的痴呆风险（致残性痴呆）呈负相关。方法以社区循环风险研究为研究背景，对3739名40 ~ 64岁的日本人（1985 ~ 1999年）进行膳食调查。采用24小时饮食回忆法估算膳食纤维摄入量。从1999年到2020年，对事件致残性痴呆进行了随访。致残性痴呆被进一步分为有或没有中风史。根据总、可溶性和不可溶性纤维摄入量的四分位数，使用Cox比例风险模型计算致残性痴呆的风险比。结果在中位19.7年的随访期间，共发生670例失能性痴呆。膳食纤维摄入量与痴呆风险呈负相关：与最低四分位数相比，膳食纤维摄入量第二、第三和最高四分位数的个体的多因素风险比（95%置信区间）分别为0.83（0.67-1.04）、0.81（0.65-1.02）和0.74(0.57-0.96)（趋势p = 0.03）。这种负相关在可溶性纤维摄入量中更为明显，并且仅限于无中风史的痴呆患者。至于含有纤维的食物，土豆，而不是蔬菜或水果，显示出类似的关联。结论：在日本普通人群中，膳食纤维的摄入量，尤其是可溶性纤维，与失能性痴呆的风险呈负相关。
ObjectivesIt has been hypothesized that dietary fiber intake has a beneficial impact on prevention of dementia, but the epidemiological evidence is scant. We sought to examine whether dietary fiber intake is inversely associated with risk of dementia requiring care under the national insurance (disabling dementia).MethodsThe study setting was the Circulatory Risk in Communities Study, involving 3739 Japanese individuals aged 40–64 years at the dietary surveys (1985–99). Dietary fiber intake was estimated using the 24-hour dietary recall method. Incident disabling dementia was followed up from 1999 through 2020. Disabling dementia was further classified into that with or without a history of stroke. Hazard ratios of disabling dementia according to quartiles of total, soluble, and insoluble fiber intake were calculated using the Cox proportional hazards model.ResultsDuring a median 19.7-year follow-up, a total of 670 cases of disabling dementia developed. Dietary fiber intake was inversely associated with risk of dementia: the multivariate hazards ratios (95% confidence intervals) were 0.83 (0.67–1.04), 0.81 (0.65–1.02), and 0.74 (0.57–0.96) for individuals with the second, third, and highest quartiles of dietary fiber intake, respectively, as compared with the lowest quartile (Pfor trend = 0.03). The inverse association was more evident for soluble fiber intake and was confined to dementia without a history of stroke. As for fiber-containing foods, potatoes, but not vegetables or fruits, showed a similar association.ConclusionsDietary fiber intake, especially soluble fiber, was inversely associated with risk of disabling dementia in a general Japanese population.