A day-centered approach to modeling cortisol: Diurnal cortisol profiles and their associations among U.S. adults
A day-centered approach to modeling cortisol: Diurnal cortisol profiles and their associations among U.S. adults
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DOI：
10.1016/j.psyneuen.2013.05.003
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发表时间：
2013-10-01
影响因子：
3.7
通讯作者：
Pieper, Carl F.
中科院分区：
文献类型：
--
作者：
Dmitrieva, Natalia O.;Almeida, David M.;Pieper, Carl F.
昼夜皮质醇是 HPA 轴活动的标志，可能是将压力源与年龄相关的健康衰退联系起来的生物机制之一。目前的研究确定了居住在美国的 1101 名成年人的日间皮质醇水平。参与者连续四天进行唾液皮质醇采集，在醒来时、醒来后 30 分钟、午餐前和睡前进行评估。使用基于潜伏时间的生长混合模型来估计 2894 个皮质醇日中日间皮质醇的常见轨迹。 3 类解决方案提供了最佳模型拟合，表明大多数研究日 (73%) 的特征是规范皮质醇模式，具有强大的皮质醇觉醒反应 (CAR)、陡峭的负昼夜斜率，以及较低的觉醒和就寝水平。相对于该曲线，其余天数的昼夜皮质醇要么全天升高（20％的天数），要么持平（7％的天数）。相对于正常轨迹，升高轨迹的特点是早晨皮质醇水平较高，而平坦轨迹的特点是就寝时间水平较高，CAR 和昼夜斜率参数较弱。相对于标准概况，会员资格的提高与年龄较大和吸烟有关。在年龄较大、男性、吸烟、使用已知会影响皮质醇输出的药物以及报告健康状况较差的参与者中，观察到皮质醇模式扁平化的可能性更大。目前的研究证明了以日为中心的生长混合模型方法在昼间皮质醇研究中的价值，表明偏离典型的昼间皮质醇强节律与年龄较大、男性、使用先前显示会影响皮质醇水平的药物、较差的健康行为和较差的自我报告健康状况有关。 (C) 2013 Elsevier Ltd. 保留所有权利。
Diurnal cortisol is a marker of HPA-axis activity that may be one of the biological mechanisms linking stressors to age-related health declines. The current study identified day-centered profiles of diurnal cortisol among 1101 adults living in the United States. Participants took part in up to four consecutive days of salivary cortisol collection, assessed at waking, 30 min post-waking, before lunch, and before bedtime. Growth mixture modeling with latent time basis was used to estimate common within-day trajectories of diurnal cortisol among 2894 cortisol days. The 3-class solution provided the best model fit, showing that the majority of study days (73%) were characterized by a Normative cortisol pattern, with a robust cortisol awakening response (CAR), a steep negative diurnal slope, coupled with low awakening and bedtime levels. Relative to this profile, diurnal cortisol on the remainder of days appeared either elevated throughout the day (20% of days) or flattened (7% of days). Relative to the normative trajectory, the elevated trajectory was distinguished by a higher morning cortisol level, whereas the flattened trajectory was characterized by a high bedtime level, with weaker CAR and diurnal slope parameters. Relative to the normative profile, elevated profile membership was associated with older age and cigarette smoking. Greater Likelihood of the flattened cortisol pattern was observed among participants who were older, male, smoked cigarettes, used medications that are known to affect cortisol output, and reported poorer health. The current study demonstrates the value of a day-centered growth mixture modeling approach to the study of diurnal cortisol, showing that deviations from the classic robust rhythm of diurnal cortisol are associated with older age, male sex, use of medications previously shown to affect cortisol levels, poorer health behaviors, and poorer self-reported health. (C) 2013 Elsevier Ltd. All rights reserved.