Effects of moderate and substantial hypoxia on erythropoietin levels in rainbow trout kidney and spleen
Effects of moderate and substantial hypoxia on erythropoietin levels in rainbow trout kidney and spleen
复制标题
DOI：
10.1242/jeb.02279
复制
发表时间：
2006-07-15
影响因子：
2.8
通讯作者：
Randall, David
中科院分区：
文献类型：
--
作者：
Lai, Jimmy C. C.;Kakuta, Izuru;Randall, David
促红细胞生成素（EPO）是一种调节哺乳动物红细胞祖细胞增殖和分化的糖蛋白激素。虽然EPO已在鱼类中被发现，但缺氧的具体功能和影响尚未得到研究。在这项研究中，我们证明了虹鳟鱼缺氧暴露时，肾脏EPO水平升高、脾脏EPO水平降低和脾-体指数（SSI）之间的关系，以及血液中血红蛋白（Hb）浓度的升高。脾收缩和随后的红细胞释放是血液中Hb浓度最初升高的原因，而EPO的作用可能是后来血液中血红蛋白浓度升高的原因。我们的数据表明，鱼类和哺乳动物的红细胞生成系统对缺氧的反应是相似的，因为鱼类的红细胞生成受EPO的影响。
Erythropoietin (EPO) is a glycoprotein hormone that regulates the proliferation and differentiation of erythroid progenitor cells in mammals. Although EPO has been identified in fish, the specific function and effects of hypoxia have not been investigated previously. In this study, we have demonstrated a relationship between increases in renal EPO levels and decreases in spleen EPO levels and spleen-somatic index (SSI), with increases in haemoglobin (Hb) concentration in the blood during hypoxia exposure in rainbow trout. Splenic contraction and the subsequent red blood cell release accounts for the initial increase in Hb concentration in the blood, whereas EPO action probably accounts for the later increases in hemoglobin concentration in the blood. Our data indicate that fish and mammalian erythropoietic systems are similar in response to hypoxia, in that erythropoiesis in fish is influenced by EPO.