YOUTH: decisions and challenges in designing an osteoporosis prevention intervention for teen girls.
YOUTH: decisions and challenges in designing an osteoporosis prevention intervention for teen girls.
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青年：为少女设计骨质疏松症预防干预措施的决定和挑战。
DOI：
10.1016/j.ypmed.2004.04.010
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发表时间：
2004
影响因子：
5.1
通讯作者：
Irving,LoriM
中科院分区：
文献类型：
--
作者：
DeBar,LynnL;Ritenbaugh,Cheryl;Vuckovic,Nancy;Stevens,VictorJ;Aickin,Mikel;Elliot,Diane;Moe,Esther;Orwoll,Eric;Ernst,Denise;Irving,LoriM
背景本文描述了青年、骨质疏松症和了解全面健康项目(SOUNE)的实验设计决策，该项目旨在测试基于健康计划的生活方式干预在14至16岁的青春期女性中增加骨密度的有效性。方法这项随机对照试验从太平洋西北部的一家大型医疗保健组织招募了患骨质疏松症(身体质量指数16-23)风险较高的青春期女性。干预的重点是改善饮食(高钙食物、水果和蔬菜)和增加体力活动(高冲击力和脊柱运动)。干预包括团体活动和个人活动。研究的主要终点是用双能X射线骨密度仪(DEXA)测量的总骨密度。结果收集了228名青春期妇女及其家庭的基线数据。本文讨论了研究人员在设计和实施试验时如何应对以下挑战：确定适当的饮食和锻炼目标以影响青少年的骨密度；选择适当的评估；以及开发适合在非学校(健康计划)环境中实施的干预措施。我们还讨论了选择特定研究人群(女性、青少年)的理由。结论青年项目是在健康计划背景下进行的极少数针对青少年的预防性研究干预措施之一。本试验中使用的许多招募和干预策略可能适合在其他基于健康计划的预防研究中采用。
BackgroundThis paper describes decisions about the experimental design for the Youth, Osteoporosis, and Understanding Total Health Project (YOUTH), a trial designed to test the efficacy of a health plan-based lifestyle intervention for increasing bone mineral density among adolescent women 14 to 16 years of age.MethodsThis randomized controlled trial recruited adolescent women who were at higher risk for developing osteoporosis (body mass index 16–23) from a large HMO in the Pacific Northwest. The intervention focused on improving diet (high calcium foods, fruits, and vegetables) and increasing physical activity (high impact and spinal motion). The intervention included both group and individual activities. The primary endpoint in the study was total bone mineral density as measured by dual-energy X-ray absorptiometry (DEXA).ResultsBaseline data were collected on the trial cohort of 228 adolescent women and their families. This paper discusses how researchers met the following challenges in designing and implementing the trial: determining appropriate dietary and exercise targets to affect bone mineral density in adolescents; choosing suitable assessments; and developing an intervention well suited for implementation in a non-school (health plan) setting. We also discuss the rationale for the specific study population chosen (females, younger adolescents).ConclusionsThe YOUTH project is one of very few preventive research interventions with adolescents conducted in a health plan setting. Many of the recruitment and intervention strategies used in this trial may be appropriate for adoption in other health plan-based prevention studies.