Cushingoid pathophysiology of old, massively obese, spontaneously hypertensive rats (SHR).
Cushingoid pathophysiology of old, massively obese, spontaneously hypertensive rats (SHR).
复制标题
老年、大量肥胖、自发性高血压大鼠（SHR）的库欣样病理生理学。
DOI：
10.1093/geronj/38.2.148
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
J. Mcmurtry
中科院分区：
文献类型：
--
作者：
B. Wexler;J. Mcmurtry
Male and female, massively obese and nonobese, spontaneously hypertensive rat (SHR) which are hypersensitive to stress were kept under quiescent conditions; they were autopsied at 15 months of age. The blood pressure of the Obese/SHR plateaued at 166 mmHg versus 198 mmHg for the nonobese/SHR. The once massive thymi vanished in the Obese/SHR accompanied by greatly enlarged adrenal glands, pituitary basophilia, greatly elevated levels of adrenocorticotrophin, corticosterone, deoxycorticosterone, aldosterone, fatty liver, hyperlipidemia, and hyperglycemia. The Obese/SHR were hyperadrenocorticoid compared with their nonobese siblings and manifested a Cushingoid spectrum of degenerative changes (e.g., thin skin, hypertension, diabetes, kidney stones, and accelerated aging). The provision of a nonstressful environment is believed to have dampened the usual chronic hyperadrenocorticism and prolonged the lifespan of the Obese/SHR.
