Effects of prenatal methamphetamine exposure on verbal memory revealed with functional magnetic resonance imaging.
Effects of prenatal methamphetamine exposure on verbal memory revealed with functional magnetic resonance imaging.
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DOI：
10.1097/dbp.0b013e3181a7ee6b
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Sowell ER
中科院分区：
文献类型：
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作者：
Lu LH;Johnson A;O'Hare ED;Bookheimer SY;Smith LM;O'Connor MJ;Sowell ER
努力了解产前甲基苯丙胺暴露对认知过程的具体影响，阻碍了高利率的同时在怀孕期间使用酒精。我们研究了在进行文字记忆任务时，不同产前致畸暴露的儿童的神经认知系统是否存在差异。参与者（7-15岁）在进行功能性磁共振成像的同时进行了言语配对联想学习任务。MA组包括14名产前接触甲基苯丙胺的儿童，其中12人同时接触酒精。他们进行了比较，9名儿童与产前酒精，但没有甲基苯丙胺暴露（ALC）和20个未暴露的控制（CON）。各组在年龄、性别或社会经济地位方面没有差异。参与者的智商和语言学习表现是使用标准化的仪器测量的。MA组比ALC组和CON组激活了更多弥散性脑区，包括已知对记忆重要的双侧内侧颞叶结构。这些组间差异在智商协变后仍然存在。更多的激活内侧颞叶结构的MA组相比，ALC组不能解释的性能差异，因为这两组在口头记忆任务的水平相似。MA组在非文字记忆过程中更弥散的激活可能反映了补偿系统的募集，以支持弱的非文字记忆网络。MA和ALC组之间的激活模式的差异表明，产前MA暴露影响的言语记忆系统的发展，超出产前酒精暴露的影响。
Efforts to understand specific effects of prenatal methamphetamine exposure on cognitive processing are hampered by high rates of concomitant alcohol use during pregnancy. We examined whether neurocognitive systems differed among children with differing prenatal teratogenic exposures when they engaged in a verbal memory task. Participants (7-15 years old) engaged in a verbal paired associate learning task while undergoing functional magnetic resonance imaging. The MA group included 14 children with prenatal methamphetamine exposure, 12 of whom had concomitant alcohol exposure. They were compared to 9 children with prenatal alcohol but not methamphetamine exposure (ALC) and 20 unexposed controls (CON). Groups did not differ in age, gender, or socioeconomic status. Participants’ IQ and verbal learning performance were measured using standardized instruments. The MA group activated more diffuse brain regions, including bilateral medial temporal structures known to be important for memory, than both the ALC and the CON groups. These group differences remained after IQ was covaried. More activation in medial temporal structures by the MA group compared to the ALC group cannot be explained by performance differences because both groups performed at similar levels on the verbal memory task. More diffuse activation in the MA group during verbal memory may reflect recruitment of compensatory systems to support a weak verbal memory network. Differences in activation patterns between the MA and ALC groups suggest that prenatal MA exposure influences the development of the verbal memory system above and beyond effects of prenatal alcohol exposure.