Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia: a voxel-based morphometric study
Regional gray matter reduction and theory of mind deficit in the early phase of schizophrenia: a voxel-based morphometric study
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DOI：
10.1111/j.1600-0447.2008.01297.x
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发表时间：
2009-03-01
影响因子：
6.7
通讯作者：
Fekete, S.
中科院分区：
文献类型：
--
作者：
Herold, R.;Feldmann, A.;Fekete, S.
我们测试了精神分裂症早期患者的心理理论(Tom)表现与脑结构变化之间的关系。对18例精神分裂症患者和21例对照组的体素形态计量(VBM)数据进行了比较。使用计算机化失语(FP)任务评估TOM技能。精神分裂症患者在FP任务中的表现明显低于健康受试者。VBM显示精神分裂症患者额叶、颞叶和皮质下某些区域的灰质密度显著降低。精神分裂症患者的不良FP表现与左侧眶前皮质和右侧颞极灰质减少有关。我们的数据表明，精神分裂症发作后不久，左侧眶前皮质和右侧颞极局部灰质减少与Tom表现不良有关。
We tested the association between theory of mind (ToM) performance and structural changes in the brains of patients in the early course of schizophrenia.Voxel-based morphometry (VBM) data of 18 patients with schizophrenia were compared with those of 21 controls. ToM skills were assessed by computerized faux pas (FP) tasks.Patients with schizophrenia performed significantly worse in FP tasks than healthy subjects. VBM revealed significantly reduced gray matter density in certain frontal, temporal and subcortical regions in patients with schizophrenia. Poor FP performance of schizophrenics correlated with gray matter reduction in the left orbitofrontal cortex and right temporal pole.Our data indicate an association between poor ToM performance and regional gray matter reduction in the left orbitofrontal cortex and right temporal pole shortly after the onset of schizophrenia.