Sealing the Broken Barrier in IBD: Intestinal Permeability, Epithelial Cells and Junctions
Sealing the Broken Barrier in IBD: Intestinal Permeability, Epithelial Cells and Junctions
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DOI：
10.2174/1389450111314120011
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发表时间：
2013-11-01
影响因子：
3.2
通讯作者：
Vetrano, Stefania
中科院分区：
文献类型：
--
作者：
Fries, Walter;Belvedere, Alessandra;Vetrano, Stefania
炎症性肠病（IBD）被认为是屏障性疾病。在最初误导性的结果之后，紊乱粘膜的致病重要性现在被广泛接受，主要是因为一定比例的IBD患者的一级亲属确实有渗透性改变，通过口腔标志物评估。在正常肠黏膜存在的情况下，必须考虑到高动态肠细胞间紧密连接的功能改变是观察到的改变的原因。事实上，在IBD中已经报道了各种跨膜和胞浆内蛋白的改变。一个重要的治疗目标是通过保存这些复合物的正确组织来维持疾病缓解。在潜在的治疗方法中，各种抗肿瘤坏死因子药物是研究得最好的药物，但其他治疗方法可能通过尚不清楚的机制收紧肠道。
Inflammatory bowel diseases (IBD) are considered barrier diseases. After misleading initial results, the pathogenic importance of a disturbed mucosa is now widely accepted, largely because a certain percentage of first-degree relatives of patients with IBD do have permeability alterations, as assessed by oral markers. In the presence of a normal appearing gut mucosa, functional alterations of the highly dynamic inter-enterocyte tight junctions have to be considered to be responsible for the observed alterations. Indeed, various alterations of the transmembrane and intracytoplasmic proteins have been reported in IBD. An important therapeutic goal is to maintain disease remission by preservation of the correct organization of these complexes. Of the potential therapeutic approaches, the various anti-TNF agents are the best-studied agents, but other treatments may tighten the gut through as yet unknown mechanisms.