A new anthraquinone derivative from the marine endophytic fungus Fusarium sp (No. b77)
A new anthraquinone derivative from the marine endophytic fungus Fusarium sp (No. b77)
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DOI：
10.1080/14786410902836701
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发表时间：
2010-01-01
影响因子：
2.2
通讯作者：
Lin, Yongcheng
中科院分区：
文献类型：
--
作者：
Shao, Changlun;Wang, Changyun;Lin, Yongcheng
从红树林真菌（No.b77）的培养物中分离得到一个新的蒽醌类化合物5-乙酰基-2-甲氧基-1，4，6-三羟基蒽醌（1）和四个已知的萘醌类化合物（2-5）。所有分离的化合物（1-5）和乙酰基衍生物（1a）通过综合分析光谱数据，特别是1D-和2D-NMR（HMQC和HMBC）光谱确定。在初步的生物测定中，化合物3对hepG 2和hep 2细胞的生长显示出强烈的抑制作用，其IC 50值分别为1.0和2.5 μ g mL（-1）。
A new anthraquinone compound, 5-acetyl-2-methoxy-1,4,6-trihydroxy-anthraquinone (1), together with four known naphthoquinones (2-5), were isolated from the culture of the mangrove fungus (No. b77). All the isolated compounds (1-5) and the acetyl derivative (1a) were established by comprehensive analysis of the spectral data, especially 1D- and 2D-NMR (HMQC and HMBC) spectra. In the primary bioassays, compound 3 showed strong inhibitory effects on the growth of hepG2 and hep2 cells, with IC50 values of 1.0 and 2.5 mu g mL(-1), respectively.