A 30 channel receive-only 7 T array for ex vivo brain hemisphere imaging
A 30 channel receive-only 7 T array for ex vivo brain hemisphere imaging
复制标题
用于离体脑半球成像的 30 通道仅接收 7 T 阵列
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
L. Wald
中科院分区：
文献类型：
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作者：
A. Mareyam;J. Polimeni;V. Alagappan;B. Fischl;L. Wald
简介：虽然死后大脑的连续切片提供了精致的空间分辨率和组织学细节，但冷冻切片之间的撕裂和扭曲使得大体积（例如大脑半球）的体积分析变得不切实际。离体样本的 MRI 提供的 3D 编码分辨率能够解析小至几百个神经元的层状和骨髓结构特征 [1]。为了实现最高的空间分辨率（<100 μm 各向同性），大脑半球的离体成像通常需要数小时的平均，但甚至需要更高的分辨率。然而，通常情况下，标准临床体内射频线圈（例如头部阵列或膝部线圈）会投入使用。小表面线圈的大型阵列非常适合离体成像，因为它们可以放置在非常靠近样品的位置，但需要专门设计的阵列几何形状和可密封的样品容器。
Introduction: While post mortem serial sectioning of the brain offers exquisite spatial resolution and histological detail, tearing and distortions between cryotome sections renders volumetric analysis of large volumes (such as a brain hemisphere) impractical. MRI of ex vivo samples provides 3D encoding at resolutions capable of resolving laminar and myeloarchitectonic features as small as a few hundred neurons [1]. To achieve the highest spatial resolutions (<100 μm isotropic), ex vivo imaging of brain hemispheres typically requires many hours of averaging, yet even higher resolution is desirable. Typically, however, a standard clinical in vivo RF coil such as a head array or knee coil is pressed into service. Large arrays of small surface coils are ideal for ex vivo imaging since they can be placed very near the sample, but a specifically designed array geometry and sealable sample container is needed.