Disruption of neuroendocrine stress responses to acute ferret odor by medial, but not central amygdala lesions in rats
Disruption of neuroendocrine stress responses to acute ferret odor by medial, but not central amygdala lesions in rats
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DOI：
10.1016/j.brainres.2009.07.011
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发表时间：
2009-09-08
期刊：
影响因子：
2.9
通讯作者：
Campeau, Serge
中科院分区：
文献类型：
--
作者：
Masini, Cher V.;Sasse, Sarah K.;Campeau, Serge
对与捕食者反应相关的神经通路的研究表明，杏仁内侧核(Mea)是参与防御行为的重要区域。然而，据我们所知，MEA在捕食者气味暴露的神经内分泌反应中的作用尚未被调查。因此，本研究探讨了干扰MEA对暴露于雪貂或对照气味的大鼠下丘脑-垂体-肾上腺皮质(HPA)轴激活的影响。用鹅膏毒素(10 mU/mW L；0.3mU L/侧)损毁SD大鼠双侧大脑中动脉。作为区域特异性的对照，另外几组大鼠被给予中央杏仁核(CEA)的损伤。恢复一周后，将大鼠暴露在小笼子里的雪貂或草莓控制毛巾中，通过测定血浆皮质酮和促肾上腺皮质激素(ACTH)水平来检测HPA轴的反应。仅在雪貂气味条件下，双侧MEA但没有CEA损伤的大鼠与假手术对照组大鼠相比，皮质酮和ACTH的释放显著减少。这些结果表明，MEA是参与HPA轴对捕食者气味反应的重要结构，这支持了先前研究类似条件下的行为反应的研究。(C)2009爱思唯尔B.V.保留所有权利。
Investigations of the neural pathways associated with responses to predators have implicated the medial amygdala (MeA) as an important region involved in defensive behaviors. To our knowledge, however, the involvement of the MeA in neuroendocrine responses to predator odor exposure has not been investigated. Therefore, the present study examined the effects of MeA disruption in rats exposed to ferret or control odor on hypothalamo-pituitary-adrenocortical (HPA) axis activation. Bilateral lesions of the MeA were made in Sprague-Dawley rats with the neurotoxin ibotenic acid (10 mu g/mu l; 0.3 mu l/side). As a control for regional specificity, additional groups of rats were given lesions in the central amygdala (CeA). One week after recovery, the rats were exposed to ferret or strawberry control towels in small cages to examine HPA axis responses as determined by plasma corticosterone and adrenocorticotropin hormone (ACTH) levels. Rats with complete bilateral MeA but not CeA lesions displayed significantly less corticosterone and ACTH release compared to sham-operated control rats only in the ferret odor conditions. These results suggest that the MeA is an important structure involved in the HPA axis responses to predator odors, in support of previous studies investigating behavioral responses under similar conditions. (C) 2009 Elsevier B.V. All rights reserved.