Disease spread through contiguity and axonal tracts in primary lateral sclerosis.
Disease spread through contiguity and axonal tracts in primary lateral sclerosis.
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DOI：
10.1002/mus.24116
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发表时间：
2014-03
期刊：
影响因子：
3.4
通讯作者：
Floeter MK
中科院分区：
文献类型：
--
作者：
Flynn L;Stephen M;Floeter MK
我们的目标是确定原发性侧索硬化症（PLS）的症状进展是否与疾病通过轴突途径或相邻皮质区域传播一致。从45个PLS患者图表中获得每个肢体和颅骨区域的症状发作日期。根据躯体位置表征在皮质中是否相邻，将新身体区域中出现的症状分为轴突性、连续性、可能连续性或不相关。在152个扩散事件中，第一个扩散事件平均分为Axonal（22）和Contivaline（23），但大多数后续扩散事件被归类为Contivaline。PLS患者的症状进展与疾病沿沿着轴突束和局部皮质扩散一致。两者在第一次扩散事件中的可能性相同，但此后局部皮质扩散占主导地位，这表明晚期变性不会通过长轴突束推进。
Our goal was to determine whether symptom progression in primary lateral sclerosis (PLS) was consistent with disease spread through axonal pathways or contiguous cortical regions. The date of symptom onset in each limb and cranial region was obtained from 45 PLS patient charts. Each appearance of symptoms in a new body region was classified as Axonal, Contiguous, Possibly Contiguous, or Unrelated according to whether the somatotopic representations were adjacent in the cortex. Of 152 spread events, the first spread event was equally divided between Axonal (22) and Contiguous (23), but the majority of subsequent spread events were classified as Contiguous. Symptom progression in PLS patients is consistent with disease spread along axonal tracts and by local cortical spread. Both were equally likely for the first spread event, but local cortical spread was predominant thereafter, suggesting that late degeneration does not advance through long axonal tracts.