The expression of thyrotrophin‐releasing hormone receptor 1 messenger ribonucleic acid in human pituitary adenomas

The expression of thyrotrophin‐releasing hormone receptor 1 messenger ribonucleic acid in human pituitary adenomas
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促甲状腺激素释放激素受体1信使核糖核酸在人垂体腺瘤中的表达

DOI:
10.1046/j.1365-2265.2001.01237.x
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发表时间:
2001
影响因子:
3.2
通讯作者:
T. Shibasaki
T. Shibasaki
中科院分区:
医学3区
文献类型:
--
作者:
Kyongsong Kim;K. Arai;N. Sanno;A. Teramoto;T. Shibasaki

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促甲状腺激素释放激素(TRH)静脉注射到肢端肥大症患者体内时,矛盾地诱导生长激素(GH)的释放,尽管目前这种作用的机制尚不清楚。几个研究小组报道,TRH受体-1(TRHR-1)mRNA的表达水平在垂体腺瘤中是可变的,并且与少数肢端肥大症患者对TRH给药的矛盾GH反应程度无关。我们的目的是比较不同类型垂体腺瘤中TRHR-1 mRNA的表达水平,并阐明这些水平是否与垂体激素对TRH的反应程度相关。
Thyrotrophin‐releasing hormone (TRH) paradoxically induces the release of growth hormone (GH) when injected intravenously into acromegalic patients, although the mechanism of this action is unknown at present. Several research groups have reported that the level of TRH receptor‐1 (TRHR‐1) mRNA expression is variable in pituitary adenomas, and does not correlate with the degree of paradoxical GH response to TRH administration in a limited number of acromegalic patients. We aimed to compare the expression levels of TRHR‐1 mRNA among various types of pituitary adenoma and to clarify whether these levels correlate with the degree of pituitary hormone response to TRH.
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发表时间: 1991
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影响因子: --
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通讯作者: Petersen,SL
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