Intolerance of uncertainty correlates with insula activation during affective ambiguity
Intolerance of uncertainty correlates with insula activation during affective ambiguity
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DOI：
10.1016/j.neulet.2007.10.030
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发表时间：
2008-01-10
影响因子：
2.5
通讯作者：
Stein, Murray B.
中科院分区：
文献类型：
--
作者：
Simmons, Alan;Matthews, Scott C.;Stein, Murray B.
对不确定性的不耐受（IU），或对不确定结果的情况的情感反应增加，是焦虑症的重要组成部分。在惊恐障碍（PD）、强迫症（OCD）和广泛性焦虑症（GAD）中观察到IU增加，并且认为IU增加与这些障碍中的功能失调行为和思维模式有关。确定哪些大脑系统与IU相关，将有助于建立一个全面的焦虑处理模型，并增加我们对焦虑症神经生物学的理解。在这里，我们使用的行为任务，墙的面孔（WOFs），在功能性磁共振成像（fMRI），探测影响和歧义，检查神经回路的IU在14（10名女性）大学年龄（18.8岁）的科目。所有受试者完成不确定性不容忍量表（IUS），焦虑敏感指数（ASI）和神经质测量（即NEO-N）。IUS评分与情感模糊时双侧脑干的激活呈正相关，而ASI和NEO-N评分均与之无关。因此，在某些类型的情绪处理过程中，IU的体验可能与双边情绪处理不确定性的程度有关。因此，先前观察到的焦虑症患者的多动症可能与不确定性过程的改变直接相关。出版社：Elsevier爱尔兰Ltd.
Intolerance of uncertainty (IU), or the increased affective response to situations with uncertain outcomes, is an important component process of anxiety disorders. Increased IU is observed in panic disorder (PD), obsessive compulsive disorder (OCD) and generalized anxiety disorder (GAD), and is thought to relate to dysfunctional behaviors and thought patterns in these disorders. Identifying what brain systems are associated with IU would contribute to a comprehensive model of anxiety processing, and increase our understanding of the neurobiology of anxiety disorders. Here, we used a behavioral task, Wall of Faces (WOFs), during functional magnetic resonance imaging (fMRI), which probes both affect and ambiguity, to examine the neural circuitry of IU in 14 (10 females) college age (18.8 years) subjects. All subjects completed the Intolerance of Uncertainty Scale (IUS), Anxiety Sensitivity Index (ASI), and a measure of neuroticism (i.e. the NEO-N). IUS scores but neither ASI nor NEO-N scores, correlated positively with activation in bilateral insula during affective ambiguity. Thus, the experience of IU during certain types of emotion processing may relate to the degree to which bilateral insula processes uncertainty. Previously observed insula hyperactivity in anxiety disorder individuals may therefore be directly linked to altered processes of uncertainty. Published by Elsevier Ireland Ltd.