Chromatin Architecture in the Fly: Living without CTCF/Cohesin Loop Extrusion?: Alternating Chromatin States Provide a Basis for Domain Architecture in Drosophila.
Chromatin Architecture in the Fly: Living without CTCF/Cohesin Loop Extrusion?: Alternating Chromatin States Provide a Basis for Domain Architecture in Drosophila.
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DOI：
10.1002/bies.201900048
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发表时间：
2019-07
期刊：
影响因子：
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通讯作者：
N. Matthews;R. White
中科院分区：
文献类型：
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作者：
N. Matthews;R. White
拓扑相关结构域（TADs）的基因组的组织似乎是一个基本的过程发生在广泛的真核生物，它可能发挥重要作用，为基因调控提供架构基础。最初的研究强调了果蝇和哺乳动物等不同生物体的染色体组织之间的显著相似之处。然而，而CCCTC结合因子（CTCF）/cohesin环挤出正在成为一个关键的机制，形成哺乳动物的拓扑结构域，在果蝇的基因组组织似乎主要取决于染色质状态域的分区。最近的工作表明一个基本的保守作用的染色质状态在建设域架构进行了讨论，并考虑从最近的研究在果蝇基因组组织的见解。
The organization of the genome into topologically associated domains (TADs) appears to be a fundamental process occurring across a wide range of eukaryote organisms, and it likely plays an important role in providing an architectural foundation for gene regulation. Initial studies emphasized the remarkable parallels between TAD organization in organisms as diverse as Drosophila and mammals. However, whereas CCCTC-binding factor (CTCF)/cohesin loop extrusion is emerging as a key mechanism for the formation of mammalian topological domains, the genome organization in Drosophila appears to depend primarily on the partitioning of chromatin state domains. Recent work suggesting a fundamental conserved role of chromatin state in building domain architecture is discussed and insights into genome organization from recent studies in Drosophila are considered.