Antioxidant activity of tocopherols, tocotrienols, and γ-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2′-azobis(2-methylpropionamidine) dihydrochloride
Antioxidant activity of tocopherols, tocotrienols, and γ-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2′-azobis(2-methylpropionamidine) dihydrochloride
复制标题
DOI：
10.1021/jf0012852
复制
发表时间：
2001-04-01
影响因子：
6.1
通讯作者：
Godber, JS
中科院分区：
文献类型：
--
作者：
Xu, ZM;Hua, N;Godber, JS
研究了从米糠中纯化的维生素 E（α-生育酚、α-生育三烯酚、γ-生育酚和γ-生育三烯酚）和γ-谷维素成分（环阿魏酸、24-亚甲基环阿魏酸和菜油酯阿魏酸）在 2,2'-偶氮双（2-甲基丙脒）二盐酸盐加速的胆固醇氧化系统中的抗氧化活性。所有成分在抑制胆固醇氧化方面均表现出显着的抗氧化活性。 24-亚甲基环阿魏酸阿魏酸的抗氧化活性最高，所有三种γ-谷维素成分的活性均高于四种维生素E成分中任何一种的活性。由于米糠中γ-谷维素的含量比维生素E高出10倍，因此γ-谷维素在减少胆固醇氧化方面可能是米糠中比维生素E更重要的抗氧化剂，而维生素E一直被认为是米糠中的主要抗氧化剂。这些成分对抗胆固醇氧化的抗氧化功能可能有助于米糠潜在的降胆固醇特性。
The antioxidant activities of vitamin E (a-tocopherol, a-tocotrienol, gamma -tocopherol, and gamma -tocotrienol) and gamma -oryzanol components (cycloartenyl ferulate, 24-methylenecycloartanyl ferulate, and campesteryl ferulate) purified from rice bran were investigated in a cholesterol oxidation system accelerated by 2,2'-azobis(2-methylpropionamidine) dihydrochloride. All components exhibited significant antioxidant activity in the inhibition of cholesterol oxidation. The highest antioxidant activity was found for 24-methylenecycloartanyl ferulate, and all three gamma -oryzanol components had activities higher than that of any of the four vitamin E components. Because the quantity of gamma -oryzanol is up to 10 times higher than that of vitamin E in rice bran, gamma -oryzanol may be a more important antioxidant of rice bran in the reduction of cholesterol oxidation than vitamin E, which has been considered to be the major antioxidant in rice bran. The antioxidant function of these components against cholesterol oxidation may contribute to the potential hypocholesterolemic property of rice bran.