Concise Synthesis of the Unnatural Sphingosine and Psychosine Enantiomer.
Concise Synthesis of the Unnatural Sphingosine and Psychosine Enantiomer.
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非天然鞘氨醇和心理氨酸对映体的简明合成。
DOI：
10.1002/ejoc.201000024
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发表时间：
2010
影响因子：
2.8
通讯作者：
Demchenko,AlexeiV
中科院分区：
文献类型：
--
作者：
Parameswar,ArchanaR;Hawkins,JacquelineA;Mydock,LaurelK;Sands,MarkS;Demchenko,AlexeiV
The accumulation of psychosine (galactosyl sphingosine) has been associated with the pathogenesis of Krabbe disease; however, the exact mechanism of its cytotoxicity remains unclear. Herein, we describe the synthesis of the unnatural enantiomer of erythro‐sphingosine, psychosine, and related derivatives thereof that would allow for the mechanistic elucidation of the toxicity of psychosine.
