Processing mitochondrial (t)RNAs New enzyme, old job
Processing mitochondrial (t)RNAs New enzyme, old job
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DOI：
10.4161/cc.8.11.8502
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发表时间：
2009-06-01
期刊：
影响因子：
4.3
通讯作者：
Holzmann, Johann
中科院分区：
文献类型：
--
作者：
Rossmanith, Walter;Holzmann, Johann
虽然不同人类线粒体RNA种类的主要合成模式在近30年前就被认识到，但假设的RNA加工机制的关键参与者之一的成分直到最近才被确定。人类线粒体RNase P，负责tRNA 5'端成熟的内切酶，被证明不同于其任何先前表征的表亲。到目前为止，它不仅缺乏被认为是诊断这类酶的RNA片段，而且它的结构更像是由多功能蛋白质拼凑而成的，这些蛋白质聚集在一起，在tRNA 5'端切割中发挥作用。（1）
While the principal mode of synthesis of the different human mitochondrial RNA species was recognized almost three decades ago, the constituents of one of the key players of the postulated RNA processing machinery were identified only recently. Human mitochondrial RNase P, the endonuclease responsible for tRNA 5' end maturation, turned out to be unlike any of its previously characterized cousins. It is not only devoid of the RNA moiety thought to be diagnostic of this type of enzymes so far, but it is instead built like a patchwork of multifunctional proteins coming together to moonlight in tRNA 5' end cleavage.(1)