Loss of Fhit expression is a predictor of poor outcome in tongue cancer.
Loss of Fhit expression is a predictor of poor outcome in tongue cancer.
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DOI：
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发表时间：
2001-02
期刊：
影响因子：
11.2
通讯作者：
Janet I. Lee;Jean-Charles Soria;Khaled A. Hassan;Diane Liu;Ximing Tang;Adel K. El-Naggar;W. K. Hong-W.
中科院分区：
文献类型：
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作者：
Janet I. Lee;Jean-Charles Soria;Khaled A. Hassan;Diane Liu;Ximing Tang;Adel K. El-Naggar;W. K. Hong-W.
FHIT基因是一个位于3p14.2的候选抑癌基因，在包括头颈部鳞状细胞癌在内的多种肿瘤中均发现有FHIT基因的缺失。为了确定FHIT在舌癌中的作用，通过免疫组织化学研究测定了来自41名患有II-IV期舌鳞状细胞癌的患者的组织样品中的Fhit表达。所有患者都接受了根治性手术治疗，平均随访时间为83个月。我们发现，41例肿瘤标本中有28例（68%）表现出Fhit染色缺乏或显著减少。Fhit表达在高分化肿瘤区域中倾向于比在低分化区域中更强，尽管这种趋势没有统计学显著性。Fhit表达与患者的年龄、性别、组织学分级或疾病的临床分期之间无显著相关性。正如所料，临床分期和淋巴结受累与预后相关。有趣的是，肿瘤表现出低水平或无Fhit表达的患者的无病生存时间显著短于肿瘤具有高Fhit表达的患者（P = 0.035，通过对数秩检验）。Fhit的预后价值与其他临床参数无关，包括疾病分期和淋巴结状态。我们的结论是，Fhit起着重要的作用，舌鳞状细胞癌的发展和Fhit表达的损失可能是一个独立的预后指标，这种肿瘤类型的患者的临床结果。
Abnormalities of FHIT, a candidate tumor suppressor gene located at 3pl4.2, have been found frequently in multiple tumor types, including head and neck squamous cell carcinoma. To determine the role of FHIT in tongue cancers, Fhit expression was determined by immunohistochemistry studies in tissue samples from 41 patients with stages II-IV squamous cell carcinomas of the tongue. All of the patients underwent curative surgical treatment with a median of 83 months of follow-up care. We found that 28 (68%) of the 41 tumor specimens demonstrated a lack of or significantly decreased staining for Fhit. Fhit expression tended to be stronger in well-differentiated tumor areas than it was in poorly differentiated areas, although this trend was not statistically significant. There was no significant correlation between Fhit expression and a patient's age or sex or the histological grade or clinical stage of disease. As expected, clinical stage and nodal involvement correlated with prognosis. Interestingly, patients whose tumors demonstrated low levels of or no Fhit expression had a significantly shorter time of disease-free survival than those whose tumors had high Fhit expression (P = 0.035, by log-rank test). This prognostic value of Fhit was independent of other clinical parameters, including stage of disease and nodal status. We conclude that Fhit plays an important role in the development of squamous cell carcinomas of the tongue and that loss of Fhit expression may be an independent prognostic indicator for clinical outcome in patients with this tumor type.