Effects of acute treatment with dopaminergic drugs on open field behavior of adult monkeys treated with lead during the first year postpartum
Effects of acute treatment with dopaminergic drugs on open field behavior of adult monkeys treated with lead during the first year postpartum
复制标题
DOI：
10.1016/0892-0362(95)02050-0
复制
发表时间：
1996-03-01
影响因子：
2.9
通讯作者：
Bowman, RE
中科院分区：
文献类型：
--
作者：
Ferguson, SA;Felipa, HN;Bowman, RE
与先前评估胆碱能系统（10）的方法类似，非人灵长类动物旷场行为的药理学挑战在此用于测量多巴胺能系统中铅诱导的潜在变化。在产后第一年用铅治疗的猴子在7岁时在开放区域急性肌肉注射阿扑吗啡（0.0-0.3 mg/kg）或氟哌啶醇（0.0-30 μ g/kg）后进行评估。持续时间的环境探索表明，可能更大的响应0.2毫克/公斤阿扑吗啡在铅治疗的猴子，然而，在所有其他行为，铅治疗的猴子对这两种药物的反应类似于控制。无论铅治疗，阿扑吗啡管理减少不活动的持续时间和增加环境探索;后者可能包括增加刻板行为，可能已被记录为环境探索。在测试的剂量范围内，氟哌啶醇对旷场行为没有显著影响。在本研究的任何部分中，铅处理的猴子不再强烈表现出先前报告的这些猴子在4-6岁时的旷场行为改变。铅处理组进入开阔视野的潜伏期略有增加，但环境探索水平与对照组相当。这些结果表明，铅相关的影响与成熟度和/或熟悉的开放领域的衰减。
A pharmacological challenge of nonhuman primate open field behavior, similar to that which pre previously assessed the cholinergic system (10), was used here to measure potential lead-induced alterations in the dopaminergic system. Monkeys that had been treated with lead during the first year postpartum were assessed at 7 years of age in the open field after acute intramuscular injection of apomorphine (0.0-0.3 mg/kg) or haloperidol (0.0-30 mu g/kg). Duration of environmental exploration indicated a possible greater responsivity to 0.2 mg/kg apomorphine in the lead-treated monkeys; however, in all other behaviors, lead-treated monkeys responded to both drugs similarly to controls. Regardless of lead treatment, apomorphine administration decreased duration of inactivity and increased environmental exploration; the latter possibly included an increase in stereotypical behavior that might have been recorded as environmental exploration. Haloperidol had no significant effects on open field behavior over the dose range tested. Open field behavioral alterations previously reported for these monkeys at 4-6 years of age were no longer strongly exhibited by the lead-treated monkeys in any portion of the current study. Latency to enter the open field was marginally increased in the lead-treated group but levels of environmental exploration were comparable to controls. These results indicate an attenuation of lead-related effects with maturity and/or familiarity with the open field.