Morphometric analysis of spinous cell in oral submucous fibrosis. Comparison with normal mucosa, leukoplakia and squamous cell carcinoma.
Morphometric analysis of spinous cell in oral submucous fibrosis. Comparison with normal mucosa, leukoplakia and squamous cell carcinoma.
复制标题
口腔粘膜下纤维化棘细胞的形态分析。
作者：
S. Gao;S. Liu;Z. Shen;L. Peng
应用交互式图像分析系统（IBAS-II）对16例口腔黏膜下纤维化（OSF）患者的棘细胞进行形态学分析。选取19个大小、形状参数，与正常黏膜、白斑、不典型增生及癌相比较。结果表明，OSF的细胞尺寸（面积、周长、各种直径）和核质比介于正常粘膜和异常增生及癌之间。前者呈进行性降低（P < 0.01），后者呈进行性升高（P < 0.01）。各组间细胞核大小差异无统计学意义（P < 0.05）。通过逐步判别分析，建立了一系列判别函数，对OSF的符合率为93.75%。细胞面积的减少和核质比的增加可反映恶性进展。细胞形态计量学模型能较好地区分OSF与其他组，提示OSF在棘细胞中出现的上皮变化具有特异性。
The morphometric analysis of the spinous cell in 16 specimens of oral submucous fibrosis (OSF) was made by using interactive image analysis system (IBAS-II). 19 parameters of the size and shape were chosen, and compared with normal mucosa, leukoplakia, dysplasia and carcinoma. The results indicated that the cell dimensions (area, perimeter, all kinds of diameter) and nuclear cytoplasmic ratio in OSF were between normal mucosa and dysplasia as well as carcinoma. The former showed a progressive decrease (P < 0.01), and the latter showed a progressive increase (P < 0.01). The dimensions of the nuclei did not show considerable differences among the groups (P < 0.05). A series of discriminant functions had been developed with stepwise discriminant analysis, the agreement ratio for OSF was 93.75%. The decrease of cell area and the increase of nuclear cytoplasmic ratio could reflect a malignant progress. The cell morphometric model could discriminate OSF well from other groups, suggesting that the change of the epithelium in OSF appearing in the spinous cell is specific itself.