Effects of the GABA receptor agonist muscimol on the turnover of brain dopamine and on the motor activity of rats.
Effects of the GABA receptor agonist muscimol on the turnover of brain dopamine and on the motor activity of rats.
复制标题
GABA 受体激动剂蝇蕈醇对脑多巴胺周转和大鼠运动活动的影响。
DOI：
10.1111/j.1600-0773.1979.tb02316.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
H. Wachtel
中科院分区：
文献类型：
--
作者：
N. Andén;M. Grabowska‐Andén;H. Wachtel
蝇蕈醇（3-羟基-5-氨基甲基异恶唑）在高剂量（10 mg/kg腹腔注射）升高脑多巴胺的浓度，降低多巴胺的利用和增加多巴胺的合成。蝇蕈醇促进而非抑制去甲肾上腺素的利用。局部应用蝇蕈醇的大鼠延髓核的抑制运动活动的剂量依赖性的方式，只有轻微的后续活动过度。这些作用与GABA产生的作用相似，支持蝇蕈醇是GABA受体激动剂的观点。
Muscimol (3-hydroxy-5-aminomethylisoxazole) at a high dose (10 mg/kg intraperitoneally) elevated the concentration of brain dopamine in rats, decreased the utilization of dopamine and increased the synthesis of dopamine. The utilization of noradrenaline was acclerated rather than retarded by muscimol. Local application of muscimol to the nucleus accumbens of rats inhibited the motor activity in a dose-dependent manner with only a slight subsequent hyperactivity. The effects are similar to those produced by GABA and they support the view that muscimol is a GABA receptor agonist.