CRK proto-oncogene maps to human chromosome band 17p13.
CRK proto-oncogene maps to human chromosome band 17p13.
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发表时间：
1993-10
期刊：
影响因子：
8
通讯作者：
T. Fioretos;N. Heisterkamp;J. Groffen;S. Benjes;C. Morris
中科院分区：
文献类型：
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作者：
T. Fioretos;N. Heisterkamp;J. Groffen;S. Benjes;C. Morris
使用鸡crk cDNA探针从人噬菌体文库中分离的基因组DNA片段显示来自人CRK基因座。我们已经使用荧光原位杂交（FISH）映射CRK远端染色体带17 p13，一个区域，表现出频繁的删除或杂合性丢失，在广泛的人类癌症。
A genomic DNA fragment, isolated from a human phage library using a chicken crk cDNA probe, was shown to derive from the human CRK locus. We have used fluorescent in situ hybridization (FISH) to map CRK distal in chromosome band 17p13, a region which demonstrates frequent deletion or loss of heterozygosity in a wide range of human cancers.