Analysis of subcellular structural tension in axonal growth of neurons
Analysis of subcellular structural tension in axonal growth of neurons
复制标题
神经元轴突生长中的亚细胞结构张力分析。
DOI：
10.1515/revneuro-2017-0047
复制
发表时间：
2018-02-01
影响因子：
4.1
通讯作者：
Guo, Jun
中科院分区：
文献类型：
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作者：
Guo, Yi Chen;Wang, Yu Xuan;Guo, Jun
轴突的生长和再生是神经系统发育和功能恢复的核心过程。它们还与某些生理和病理条件有关。几十年来，人们一致认为，新的轴突是通过在生长锥处添加新物质形成的。然而，利用现有技术，我们已经研究了神经细胞的结构张力，这使我们假设一些亚细胞结构张力协同促进轴突的生长和再生。本文综述了亚细胞结构张力、渗透压、微丝和微管依赖性张力在促进轴突生长中的调控作用。通过建立挤压模型，分析了轴突伸长的力学机制，为轴突生长提供了新的视角，并为进一步的研究提供了启示。
The growth and regeneration of axons are the core processes of nervous system development and functional recovery. They are also related to certain physiological and pathological conditions. For decades, it has been the consensus that a new axon is formed by adding new material at the growth cone. However, using the existing technology, we have studied the structural tension of the nerve cell, which led us to hypothesize that some subcellular structural tensions contribute synergistically to axonal growth and regeneration. In this review, we classified the subcellular structural tension, osmotic pressure, microfilament and microtubule-dependent tension involved controllably in promoting axonal growth. A squeezing model was built to analyze the mechanical mechanism underlying axonal elongation, which may provide a new view of axonal growth and inspire further research.