Motion Correction in Dual Gated Cardiac PET Using Mass-Preserving Image Registration
Motion Correction in Dual Gated Cardiac PET Using Mass-Preserving Image Registration
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DOI：
10.1109/tmi.2011.2175402
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发表时间：
2012-03-01
影响因子：
10.6
通讯作者：
Schaefers, Klaus P.
中科院分区：
文献类型：
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作者：
Gigengack, Fabian;Ruthotto, Lars;Schaefers, Klaus P.
呼吸和心脏运动会导致人类心脏的正电子发射断层扫描 (PET) 研究中的图像质量下降。在本文中，我们提出了一种基于双门控和保质超弹性图像配准的运动校正新方法。因此，我们考虑了由高度非刚性心脏运动引起的强度调制。这导致了准确而真实的运动估计，这些估计在软件模型数据上进行了定量验证，并使用硬件模型转移到临床相关数据。对于患者数据，所提出的方法首先在 21 名患者的高统计量（20 分钟扫描）双门控研究中进行评估。结果表明，所提出的方法可以正确校正双心脏和呼吸运动的 PET 图像。在第二项研究中，相同患者的列表模式数据被裁剪为适合临床实践的合理扫描时间（3 分钟）。这项低统计研究不仅表明了我们的方法的临床适用性，而且证明了其对超弹性正则化获得的噪声的鲁棒性。
Respiratory and cardiac motion leads to image degradation in positron emission tomography (PET) studies of the human heart. In this paper we present a novel approach to motion correction based on dual gating and mass-preserving hyperelastic image registration. Thereby, we account for intensity modulations caused by the highly nonrigid cardiac motion. This leads to accurate and realistic motion estimates which are quantitatively validated on software phantom data and carried over to clinically relevant data using a hardware phantom. For patient data, the proposed method is first evaluated in a high statistic (20 min scans) dual gating study of 21 patients. It is shown that the proposed approach properly corrects PET images for dual-cardiac as well as respiratory-motion. In a second study the list mode data of the same patients is cropped to a scan time reasonable for clinical practice (3 min). This low statistic study not only shows the clinical applicability of our method but also demonstrates its robustness against noise obtained by hyperelastic regularization.