Lower availability of striatal dopamine transporter in generalized anxiety disorder: a preliminary two-ligand SPECT study
Lower availability of striatal dopamine transporter in generalized anxiety disorder: a preliminary two-ligand SPECT study
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DOI：
10.1097/yic.0000000000000067
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发表时间：
2015-05-01
影响因子：
2.6
通讯作者：
Yang, Yen Kuang
中科院分区：
文献类型：
--
作者：
Lee, Lan-Ting;Tsai, Hsin Chun;Yang, Yen Kuang
多巴胺和5-羟色胺已被间接发现与广泛性焦虑症（GAD）有关。本研究的目的是检查广泛性焦虑症患者纹状体多巴胺转运体（DAT）和中脑5-羟色胺转运体（SERT）的可用性。招募了12名GAD患者和12名性别匹配、年龄匹配和吸烟状况匹配的健康对照。以[Tc-99 m] TRODAT-1和[I-123]ADAM为配体，用单光子发射计算机断层扫描法估算DAT和SERT的有效性。由于实验时缺乏放射性配体，ADAM研究中6名GAD参与者的数据缺失。广泛性焦虑症患者纹状体内DAT含量显著低于健康对照组。然而，两组之间的SERT可用性没有差异。纹状体DAT水平的结果表明，在GAD的病理生理学的潜在作用。版权所有（C）2015威科医疗集团All rights reserved.
Dopamine and serotonin have been indirectly found to be associated with generalized anxiety disorder (GAD). The aims of this study were to examine the availabilities of the striatal dopamine transporter (DAT) and the midbrain serotonin transporter (SERT) in patients with GAD. 12 patients with GAD and 12 sex-matched, age-matched, and smoking status-matched healthy controls were recruited. The availabilities of DAT and SERT were approximated using single-photon emission computed tomography, with [Tc-99m] TRODAT-1 and [I-123]ADAM as the ligands. There were several missing data for six participants with GAD in the ADAM study because of a lack of the radioligand at the time of the experiment. The DAT availability in the striatum was significantly lower in the patients with GAD than in the healthy controls. However, the SERT availability did not differ between the two groups. The results with respect to the striatal DAT level suggested a potential role in the pathophysiology of GAD. Copyright (C) 2015 Wolters Kluwer Health, Inc. All rights reserved.